Naqvi Iftikhar Haider, Mahmood Khalid, Salekeen Sirajus, Akhter Syed Tehseen
Dow University of Health Sciences Civil Hospital Karachi, Department of Internal Medicine, Karachi, Pakistan.
Turk J Gastroenterol. 2013;24(5):415-22. doi: 10.4318/tjg.2013.0637.
BACKGROUND/AIMS: Malnutrition is a significant problem in cirrhosis of the liver worldwide. Inadequate data is available on the nutritional status of Pakistani patients. This study aimed to determine the frequency and severity of malnutrition in patients having cirrhosis of the liver and to compare the degree of malnutrition with the severity of liver disease.
Two hundred ninety-eight patients with liver cirrhosis were included in the study. Nutritional status was assessed using the Royal Free Hospital Global Assessment scheme for cirrhotics. The patients were categorized into well-nourished, and mild to moderately and severely malnourished. Various degrees of malnutrition were compared with severity of disease according to Child-Pugh staging.
In the 298 patients with liver cirrhosis, hepatitis C (54,36%) and B (35,90%) were the commonest aetiologies, followed by autoimmune hepatitis (3,35%), primary billiary cirrhosis (2,34%), Wilson's disease (1,34%), haemochromatosis (1,0%), cryptogenic cirrhosis (1,0%), and alcohol being the rare cause (0,67%). 14,42% patients were well-nourished, (54,02%) were mildto moderately malnourished and (31,54%) were severely malnourished. Malnutrition is more frequent in virus-related cirrhosis, and the degree of malnutrition increases with increasing clinical severity as assessed by Child- Pugh stages with statistically significant p-value of 0.001.
Moderate to severe malnutrition among diverse aetiologies of cirrhosis is quite common in Pakistan. The degree of malnutrition increases with increasing clinical severity of cirrhosis of liver.
背景/目的：营养不良是全球范围内肝硬化的一个重要问题。关于巴基斯坦患者营养状况的数据不足。本研究旨在确定肝硬化患者营养不良的发生率和严重程度，并将营养不良程度与肝病严重程度进行比较。
本研究纳入了298例肝硬化患者。使用皇家自由医院全球肝硬化评估方案评估营养状况。患者被分为营养良好、轻度至中度营养不良和重度营养不良。根据Child-Pugh分期，将不同程度的营养不良与疾病严重程度进行比较。
在298例肝硬化患者中，丙型肝炎（54.36%）和乙型肝炎（35.90%）是最常见的病因，其次是自身免疫性肝炎（3.35%）、原发性胆汁性肝硬化（2.34%）、威尔逊病（1.34%）、血色素沉着症（1.0%）、隐源性肝硬化（1.0%），酒精是罕见病因（0.67%）。14.42%的患者营养良好，54.02%的患者轻度至中度营养不良，31.54%的患者重度营养不良。病毒相关性肝硬化中营养不良更为常见，且根据Child-Pugh分期评估，随着临床严重程度的增加，营养不良程度也增加，p值为0.001，具有统计学意义。
在巴基斯坦，不同病因的肝硬化患者中，中度至重度营养不良相当常见。营养不良程度随着肝硬化临床严重程度的增加而增加。
