A10型口蹄疫病毒的抗原位点
Antigenic sites on foot-and-mouth disease virus type A10.
作者信息
Thomas A A, Woortmeijer R J, Puijk W, Barteling S J
机构信息
Central Veterinary Institute, Department of Virology, Lelystad, The Netherlands.
出版信息
J Virol. 1988 Aug;62(8):2782-9. doi: 10.1128/JVI.62.8.2782-2789.1988.
Abstract
A set of monoclonal antibodies was used to isolate nonneutralizable foot-and-mouth disease virus variants, and the RNAs of the variants were sequenced. Cross-neutralization studies and mapping of the amino acid changes indicated two major antigenic sites. The first site was trypsin sensitive and included the VP1 140 to 160 sequence. The second site was trypsin insensitive and included mainly VP3 residues. Two minor sites were located near VP1 169 and on the C terminus of VP1. Comparison with poliovirus type 1 and human rhinovirus 14 showed a similarity in the immunogenicity of comparable sites on the viruses.
摘要
使用一组单克隆抗体分离不可中和的口蹄疫病毒变体，并对这些变体的RNA进行测序。交叉中和研究和氨基酸变化图谱显示了两个主要抗原位点。第一个位点对胰蛋白酶敏感，包括VP1的140至160序列。第二个位点对胰蛋白酶不敏感，主要包括VP3残基。两个次要位点位于VP1 169附近和VP1的C末端。与1型脊髓灰质炎病毒和人鼻病毒14的比较表明，这些病毒上可比位点的免疫原性具有相似性。
相似文献
1
Antigenic sites on foot-and-mouth disease virus type A10.A10型口蹄疫病毒的抗原位点
J Virol. 1988 Aug;62(8):2782-9. doi: 10.1128/JVI.62.8.2782-2789.1988.
2
Analysis of neutralizing antigenic sites on the surface of type A12 foot-and-mouth disease virus.A12型口蹄疫病毒表面中和抗原位点分析
J Virol. 1989 May;63(5):2143-51. doi: 10.1128/JVI.63.5.2143-2151.1989.
3
Identification of neutralizing antigenic sites on VP1 and VP2 of type A5 foot-and-mouth disease virus, defined by neutralization-resistant variants.由抗中和变异株定义的A5型口蹄疫病毒VP1和VP2上中和抗原位点的鉴定
J Virol. 1991 May;65(5):2518-24. doi: 10.1128/JVI.65.5.2518-2524.1991.
4
Antigenicity and immunogenicity of synthetic peptides of foot-and-mouth disease virus.口蹄疫病毒合成肽的抗原性和免疫原性
J Gen Virol. 1987 Feb;68 ( Pt 2):305-14. doi: 10.1099/0022-1317-68-2-305.
5
Neutralization of foot-and-mouth disease virus can be mediated through any of at least three separate antigenic sites.口蹄疫病毒的中和作用可通过至少三个不同抗原位点中的任何一个来介导。
J Gen Virol. 1987 Jun;68 ( Pt 6):1637-47. doi: 10.1099/0022-1317-68-6-1637.
6
Principal and subsidiary antigenic sites of VP1 involved in the neutralization of poliovirus type 3.参与3型脊髓灰质炎病毒中和作用的VP1主要和次要抗原位点。
J Gen Virol. 1985 May;66 ( Pt 5):1159-65. doi: 10.1099/0022-1317-66-5-1159.
7
The main antigenic determinant detected by neutralizing monoclonal antibodies on the intact foot-and-mouth disease virus particle is absent from isolated VPI.在完整的口蹄疫病毒颗粒上，通过中和单克隆抗体检测到的主要抗原决定簇在分离出的VPI中不存在。
J Gen Virol. 1983 May;64(Pt 5):1193-8. doi: 10.1099/0022-1317-64-5-1193.
8
Host cell selection of antigenic variants of foot-and-mouth disease virus.口蹄疫病毒抗原变异株的宿主细胞选择
J Gen Virol. 1989 Jan;70 ( Pt 1):45-57. doi: 10.1099/0022-1317-70-1-45.
9
Neutralization sites of type O1 foot-and-mouth disease virus defined by monoclonal antibodies and neutralization-escape virus variants.由单克隆抗体和中和逃逸病毒变体所定义的O1型口蹄疫病毒的中和位点
Virology. 1988 Jan;162(1):21-9. doi: 10.1016/0042-6822(88)90390-x.
10
Monoclonal antibodies, against O1 serotype foot-and-mouth disease virus, from a natural bovine host, recognize similar antigenic features to those defined by the mouse.来自天然牛宿主的抗O1血清型口蹄疫病毒单克隆抗体识别与小鼠所定义的相似抗原特征。
J Gen Virol. 1998 Jul;79 ( Pt 7):1687-97. doi: 10.1099/0022-1317-79-7-1687.
引用本文的文献
1
Foot-and-mouth disease in Asia.亚洲的口蹄疫
Virus Res. 2025 Jan;351:199514. doi: 10.1016/j.virusres.2024.199514. Epub 2024 Dec 19.
2
Establishment of the Foot-and-Mouth Disease Virus Type Asia1 Expressing the HiBiT Protein: A Useful Tool for a NanoBiT Split Luciferase Assay.建立表达 HiBiT 蛋白的口蹄疫病毒 Asia1 型：用于 NanoBiT 分裂荧光素酶测定的有用工具。
Viruses. 2024 Jun 21;16(7):1002. doi: 10.3390/v16071002.
3
4
Isolation, molecular characterization, and genetic diversity of recently isolated foot-and-mouth disease virus serotype A in Egypt.埃及近期分离的口蹄疫病毒 A 型的分离、分子特征和遗传多样性。
PLoS One. 2023 Dec 5;18(12):e0295319. doi: 10.1371/journal.pone.0295319. eCollection 2023.
5
Conserved antigen structures and antibody-driven variations on foot-and-mouth disease virus serotype A revealed by bovine neutralizing monoclonal antibodies.牛源中和性单克隆抗体揭示的口蹄疫病毒血清型 A 的保守抗原结构和抗体驱动的变异。
PLoS Pathog. 2023 Nov 20;19(11):e1011811. doi: 10.1371/journal.ppat.1011811. eCollection 2023 Nov.
6
B and T Cell Epitopes of the Incursionary Foot-and-Mouth Disease Virus Serotype SAT2 for Vaccine Development.入侵性口蹄疫病毒血清型 SAT2 的 B 和 T 细胞表位，用于疫苗开发。
Viruses. 2023 Mar 21;15(3):797. doi: 10.3390/v15030797.
7
Mapping of foot-and-mouth disease virus antigenic sites recognized by single-domain antibodies reveals different 146S particle specific sites and particle flexibility.单域抗体识别的口蹄疫病毒抗原位点图谱揭示了不同的146S颗粒特异性位点和颗粒灵活性。
Front Vet Sci. 2023 Jan 9;9:1040802. doi: 10.3389/fvets.2022.1040802. eCollection 2022.
8
Establishing an In Vitro System to Assess How Specific Antibodies Drive the Evolution of Foot-and-Mouth Disease Virus.建立一个体外系统以评估特定抗体如何驱动口蹄疫病毒的进化。
Viruses. 2022 Aug 19;14(8):1820. doi: 10.3390/v14081820.
9
Foot-and-mouth disease virus VP1 promotes viral replication by regulating the expression of chemokines and GBP1.口蹄疫病毒VP1通过调节趋化因子和鸟苷结合蛋白1（GBP1）的表达促进病毒复制。
Front Vet Sci. 2022 Jul 22;9:937409. doi: 10.3389/fvets.2022.937409. eCollection 2022.
10
Characterization of the O/ME-SA/Ind-2001d foot-and-mouth disease virus epidemic recorded in the Maghreb during 2014-2015.2014-2015 年期间在马格里布记录的 O/ME-SA/Ind-2001d 口蹄疫病毒流行的特征。
Transbound Emerg Dis. 2022 Sep;69(5):e2641-e2652. doi: 10.1111/tbed.14611. Epub 2022 Jun 22.
本文引用的文献
1
Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence.通过用根据病毒核苷酸序列预测的化学合成肽进行免疫接种来预防口蹄疫。
Nature. 1982 Jul 1;298(5869):30-3. doi: 10.1038/298030a0.
2
The nucleotide sequence of cDNA coding for the structural proteins of foot-and-mouth disease virus.编码口蹄疫病毒结构蛋白的cDNA的核苷酸序列。
Gene. 1982 Feb;17(2):153-61. doi: 10.1016/0378-1119(82)90068-3.
3
A study of the cross-reacting antigens on the intact foot-and-mouth disease virus and its 12S Subunits with antisera against the structural proteins.一项关于完整口蹄疫病毒及其12S亚基上与抗结构蛋白抗血清发生交叉反应的抗原的研究。
J Gen Virol. 1980 Nov;51(Pt 1):107-16. doi: 10.1099/0022-1317-51-1-107.
4
Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.利用肽合成技术探测病毒抗原的表位，分辨率可达单个氨基酸水平。
Proc Natl Acad Sci U S A. 1984 Jul;81(13):3998-4002. doi: 10.1073/pnas.81.13.3998.
5
The main antigenic determinant detected by neutralizing monoclonal antibodies on the intact foot-and-mouth disease virus particle is absent from isolated VPI.在完整的口蹄疫病毒颗粒上，通过中和单克隆抗体检测到的主要抗原决定簇在分离出的VPI中不存在。
J Gen Virol. 1983 May;64(Pt 5):1193-8. doi: 10.1099/0022-1317-64-5-1193.
6
Location and characterization of the antigenic portion of the FMDV immunizing protein.口蹄疫病毒免疫蛋白抗原部分的定位与特性分析
J Gen Virol. 1982 Apr;59(Pt 2):295-306. doi: 10.1099/0022-1317-59-2-295.
7
DNA sequence analysis by primed synthesis.通过引物合成进行DNA序列分析。
Methods Enzymol. 1980;65(1):560-80. doi: 10.1016/s0076-6879(80)65060-5.
8
[Neutralization of the infective power of the foot-and-mouth disease virus in cell culture by using serums from pigs immunized with a purified viral protein].
C R Acad Hebd Seances Acad Sci D. 1973 Jun 18;276(25):3399-401.
9
Surface structure of foot-and-mouth disease virus.
J Gen Virol. 1969 Apr;4(3):313-20. doi: 10.1099/0022-1317-4-3-313.
10
Surface structure and RNA-protein interactions of foot-and-mouth disease virus.
J Gen Virol. 1987 Jun;68 ( Pt 6):1649-58. doi: 10.1099/0022-1317-68-6-1649.
Zotero 插件