Carlos-Fabuel Laura, Marzal-Gamarra Cristina, Martí-Álamo Silvia, Mancheño-Franch Aisha
DDS. Master in Oral Medicine and Surgery. University of Valencia. Valencia (Spain).
J Clin Exp Dent. 2012 Oct 1;4(4):e244-7. doi: 10.4317/jced.50868. eCollection 2012 Oct.
The use of different facial cosmetic fillers has increased in recent years. The introduction of apparently inert substances in the epidermis can give rise to foreign body granulomatous reactions. Objetives: A literature review is made of the foreign body granulomatous reactions to cosmetic fillers.
A PubMed-Medline search was made using the following keywords: "granulomatous reactions", "foreign body reactions", "esthetic fillers", "cosmetic fillers". The search was limited to articles published in English and Spanish during the last 10 years. A total of 22 articles were reviewed.
A great variety of substances have been found to give rise to foreign body granulomatous reactions. The most common locations are the upper and lower lip and the nasogenian sulcus. The clinical presentation is variable and can range from single or multiple nodules to diffuse facial swelling of hard-elastic consistency, accompanied by reddening. Most lesions are asymptomatic or cause only mild discomfort. The literature describes different treatments, including systemic corticosteroids, local tacrolimus infiltrations, minocycline, retinoids, allopurinol, 5% imiquimod, and surgical removal.
In view of the current demand for esthetic treatments, the use of cosmetic fillers can be expected to increase in future, together with the incidence of complications. Key words:Esthetic fillers, granulomatous reactions, foreign body reactions, cosmetic fillers.
近年来，不同面部美容填充剂的使用有所增加。在表皮引入看似惰性的物质可能会引发异物肉芽肿反应。目的：对美容填充剂的异物肉芽肿反应进行文献综述。
使用以下关键词在PubMed-Medline上进行检索：“肉芽肿反应”、“异物反应”、“美容填充剂”、“化妆品填充剂”。检索仅限于过去10年以英文和西班牙文发表的文章。共审查了22篇文章。
已发现多种物质会引发异物肉芽肿反应。最常见的部位是上唇和下唇以及鼻唇沟。临床表现各异，可从单个或多个结节到质地硬弹性的面部弥漫性肿胀，并伴有发红。大多数病变无症状或仅引起轻微不适。文献描述了不同的治疗方法，包括全身用皮质类固醇、局部他克莫司浸润、米诺环素、维甲酸、别嘌呤醇、5%咪喹莫特以及手术切除。
鉴于目前对美容治疗的需求，预计未来美容填充剂的使用将增加，并发症的发生率也会增加。关键词：美容填充剂、肉芽肿反应、异物反应、化妆品填充剂。
