Tasaka K, Mio M, Izushi K, Akagi M, Makino T
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Agents Actions. 1988 Apr;23(3-4):157-60. doi: 10.1007/BF02142527.
For centuries, Ganoderma lucidum has been used in Oriental medicine for the treatment of chronic bronchitis. Sequential fractions of the culture medium of this plant revealed that one of the active constituents was cyclooctasulfur. The latter effectively inhibited histamine release from rat peritoneal mast cells and impeded 45Ca uptake into these cells without affecting the cyclic AMP content. SDS-PAGE analysis indicated that cyclooctasulfur induced some changes in protein bands obtained from the membrane fraction of mast cells, suggesting that this compound interacts with membrane proteins so as to inhibit 45Ca uptake, and that this may be the main cause of histamine release inhibition.
几个世纪以来，灵芝一直被用于东方医学中治疗慢性支气管炎。对这种植物培养基的连续级分分析表明，其中一种活性成分是环辛硫。环辛硫能有效抑制大鼠腹膜肥大细胞释放组胺，并阻止45Ca进入这些细胞，而不影响细胞内环磷酸腺苷（cAMP）的含量。十二烷基硫酸钠-聚丙烯酰胺凝胶电泳（SDS-PAGE）分析表明，环辛硫使从肥大细胞膜组分获得的蛋白条带发生了一些变化，这表明该化合物与膜蛋白相互作用，从而抑制45Ca的摄取，这可能是组胺释放受抑制的主要原因。
