生长抑素刺激肥大细胞分泌组胺。
Histamine secretion from mast cells stimulated with somatostatin.
作者信息
Kassessinoff T A, Pearce F L
机构信息
Department of Chemistry, University College London, UK.
出版信息
Agents Actions. 1988 Apr;23(3-4):211-3. doi: 10.1007/BF02142543.
Histamine release from isolated mast cells stimulated with somatostatin resembled that induced by other basic agents. The process was rapid, independent of added calcium or phospholipids, non-cytotoxic, species and tissue specific, not mediated through cell-fixed antibodies or glucoreceptors, and inhibited by antagonists of the polyamine receptor. Somatostatin and other polycations may then act through a common receptor or binding site on the mast cell membrane.
生长抑素刺激分离的肥大细胞释放组胺的过程类似于其他碱性物质所诱导的过程。该过程迅速，不依赖于添加的钙或磷脂，无细胞毒性，具有物种和组织特异性，不通过细胞固定抗体或葡萄糖受体介导，且受多胺受体拮抗剂抑制。生长抑素和其他聚阳离子可能通过肥大细胞膜上的共同受体或结合位点发挥作用。
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