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大鼠和豚鼠心脏及其他肥大细胞的分离与特性

Isolation and properties of cardiac and other mast cells from the rat and guinea-pig.

作者信息

Ali H, Pearce F L

出版信息

Agents Actions. 1985 Apr;16(3-4):138-40. doi: 10.1007/BF01983121.

DOI:10.1007/BF01983121
PMID:2409761
Abstract

A method is described for the enzymic dispersion into their component cells of cardiac tissues from the rat and guinea-pig. The resulting suspensions contain ca. 1% free mast cells and exhibit a low spontaneous release of histamine. The reactivity of these cells towards a number of defined chemical histamine liberators is compared with that of other connective tissue mast cells from the same animals. The results obtained are discussed in terms of the general functional heterogeneity of mast cells from different locations.

摘要

本文描述了一种将大鼠和豚鼠心脏组织酶解分散成单个细胞的方法。所得悬浮液中约含1%的游离肥大细胞，且组胺的自发释放率较低。将这些细胞对多种特定化学组胺释放剂的反应性与来自相同动物的其他结缔组织肥大细胞的反应性进行了比较。根据不同位置肥大细胞的一般功能异质性对所得结果进行了讨论。

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1
Isolation and properties of cardiac and other mast cells from the rat and guinea-pig.大鼠和豚鼠心脏及其他肥大细胞的分离与特性
Agents Actions. 1985 Apr;16(3-4):138-40. doi: 10.1007/BF01983121.
2
Mast cells isolated from guinea-pig lung: characterization and studies on histamine secretion.从豚鼠肺中分离的肥大细胞：特性及组胺分泌研究
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Role of protein phosphatases inhibitors on the histamine release and the functional desensitization in human lung mast cells.蛋白磷酸酶抑制剂对人肺肥大细胞组胺释放及功能脱敏的作用

本文引用的文献

1
Mast cells isolated from guinea-pig lung: characterization and studies on histamine secretion.从豚鼠肺中分离的肥大细胞：特性及组胺分泌研究
Agents Actions. 1983 Apr;13(2-3):122-6. doi: 10.1007/BF01967313.
2
Histamine secretion from mast cells treated with chlortetracycline (aureomycin): a novel calcium ionophore.用金霉素（氯四环素）处理肥大细胞后组胺的分泌：一种新型钙离子载体。
Agents Actions. 1983 Apr;13(2-3):117-22. doi: 10.1007/BF01967312.
3
Dysrhythmias caused by histamine release in guinea pig and human hearts.组胺释放引起的豚鼠和人类心脏心律失常。
J Res Med Sci. 2014 Oct;19(10):923-7.
4
The emerging prominence of the cardiac mast cell as a potent mediator of adverse myocardial remodeling.心脏肥大细胞作为不良心肌重塑的有力介质日益突出。
Methods Mol Biol. 2015;1220:121-39. doi: 10.1007/978-1-4939-1568-2_8.
5
Cardiac mast cells: the centrepiece in adverse myocardial remodelling.心肌肥大细胞：不良心肌重构的核心。
Cardiovasc Res. 2011 Jan 1;89(1):12-9. doi: 10.1093/cvr/cvq272. Epub 2010 Aug 24.
6
The long-acting beta-adrenoceptor agonist, indacaterol, inhibits IgE-dependent responses of human lung mast cells.长效β肾上腺素受体激动剂，茚达特罗，抑制人肺肥大细胞 IgE 依赖性反应。
Br J Pharmacol. 2009 Sep;158(1):267-76. doi: 10.1111/j.1476-5381.2009.00178.x. Epub 2009 Apr 9.
7
Influence of beta2-adrenoceptor gene polymorphisms on beta2-adrenoceptor-mediated responses in human lung mast cells.β2 -肾上腺素能受体基因多态性对人肺肥大细胞中β2 -肾上腺素能受体介导反应的影响。
Br J Pharmacol. 2007 Oct;152(3):323-31. doi: 10.1038/sj.bjp.0707400. Epub 2007 Jul 23.
8
Role of calcineurin in the regulation of human lung mast cell and basophil function by cyclosporine and FK506.钙调神经磷酸酶在环孢素和FK506对人肺肥大细胞及嗜碱性粒细胞功能调节中的作用
Br J Pharmacol. 2007 Feb;150(4):509-18. doi: 10.1038/sj.bjp.0707002. Epub 2007 Jan 2.
9
Prostaglandin E2 activates EP2 receptors to inhibit human lung mast cell degranulation.前列腺素E2激活EP2受体以抑制人肺肥大细胞脱颗粒。
Br J Pharmacol. 2006 Apr;147(7):707-13. doi: 10.1038/sj.bjp.0706664.
10
Influence of agonist intrinsic activity on the desensitisation of beta2-adrenoceptor-mediated responses in mast cells.激动剂内在活性对肥大细胞中β2-肾上腺素能受体介导反应脱敏的影响。
Br J Pharmacol. 2004 Sep;143(1):71-80. doi: 10.1038/sj.bjp.0705905. Epub 2004 Aug 2.
Klin Wochenschr. 1982 Sep 1;60(17):965-71. doi: 10.1007/BF01716956.
4
Functional heterogeneity of mast cells from different species and tissues.来自不同物种和组织的肥大细胞的功能异质性。
Klin Wochenschr. 1982 Sep 1;60(17):954-7. doi: 10.1007/BF01716954.
5
Differential reactivity of isolated mast cells from the rat and guinea pig.大鼠和豚鼠分离肥大细胞的差异反应性。
Eur J Pharmacol. 1980 Sep 5;66(4):339-45. doi: 10.1016/0014-2999(80)90466-5.
6
Isolation and some properties of mast cells from the mesentery of the rat and guinea pig.大鼠和豚鼠肠系膜肥大细胞的分离及其某些特性
Agents Actions. 1980 Apr;10(1 Pt 2):124-31. doi: 10.1007/BF02024193.
7
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J Physiol. 1966 Jun;184(4):924-41. doi: 10.1113/jphysiol.1966.sp007957.