佛波酯、丝氨酸磷脂和钙对肥大细胞和嗜碱性粒细胞组胺释放的影响。

Effects of phorbol ester, serine phospholipids, and calcium on histamine release from mast cells and basophils.

作者信息

Cunniffe T M, Pearce F L

机构信息

Department of Chemistry, University College London, UK.

出版信息

Agents Actions. 1988 Apr;23(3-4):170-2. doi: 10.1007/BF02142531.

DOI:10.1007/BF02142531

Abstract

The effects of calcium, serine phospholipids and the phorbol ester tetradecanoylphorbol acetate (TPA), a known activator of protein kinase C, have been examined on mastocytes from different sources. A complex and differential interaction between these agents and histamine secretion was observed in human basophil leucocytes and in peritoneal mast cells from the rat, mouse and hamster. On this basis, the possible role of kinase C in histamine release is discussed.

摘要

钙、丝氨酸磷脂以及佛波酯十四酰佛波醇乙酸酯（TPA，一种已知的蛋白激酶C激活剂）对不同来源肥大细胞的作用已得到研究。在人嗜碱性白细胞以及大鼠、小鼠和仓鼠的腹膜肥大细胞中，观察到了这些物质与组胺分泌之间复杂且有差异的相互作用。在此基础上，讨论了激酶C在组胺释放中的可能作用。

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本文引用的文献

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Different responses of rodent mast cells to lysophosphatidylserine.啮齿动物肥大细胞对溶血磷脂酰丝氨酸的不同反应。

Agents Actions. 1984 Jun;14(5-6):613-8. doi: 10.1007/BF01978895.

2

Synergistic action of protein kinase C and calcium for histamine release from rat peritoneal mast cells.蛋白激酶C与钙对大鼠腹膜肥大细胞组胺释放的协同作用。

Biochem Biophys Res Commun. 1984 Jun 15;121(2):573-8. doi: 10.1016/0006-291x(84)90220-1.

3

Release of histamine from human leukocytes stimulated with the tumor-promoting phorbol diesters. I. Characterization of the response.用促肿瘤佛波酯刺激人白细胞释放组胺。I. 反应特性

J Immunol. 1981 Feb;126(2):570-4.

4

Synergism between lysophosphatidylserine and the phorbol ester tetradecanoylphorbolacetate in rat mast cells.溶血磷脂酰丝氨酸与佛波酯十四酰佛波醇乙酸酯在大鼠肥大细胞中的协同作用。

Life Sci. 1985 Apr 22;36(16):1581-7. doi: 10.1016/0024-3205(85)90383-2.

5

Characterization of the effects of phorbol esters on rat mast cell secretion.佛波酯对大鼠肥大细胞分泌作用的特性研究

J Immunol. 1985 Jan;134(1):548-55.

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Biochem Biophys Res Commun. 1986 Jun 30;137(3):1112-8. doi: 10.1016/0006-291x(86)90340-2.

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