一种具有游离羟基的功能化聚酯促进成骨细胞和人骨髓间充质干细胞细胞外基质的矿化。
A functional polyester carrying free hydroxyl groups promotes the mineralization of osteoblast and human mesenchymal stem cell extracellular matrix.
机构信息
Department of Ophthalmology, Shanghai Ninth Peoples' Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Rd, Shanghai 200011, People's Republic of China; Departments of Bioengineering, Chemical Engineering, Surgery, and the McGowan Institute, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA 15261, USA.
Departments of Bioengineering, Chemical Engineering, Surgery, and the McGowan Institute, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA 15261, USA; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, People's Republic of China.
出版信息
Acta Biomater. 2014 Jun;10(6):2814-23. doi: 10.1016/j.actbio.2014.02.018. Epub 2014 Feb 18.
Functional groups can control biointerfaces and provide a simple way to make therapeutic materials. We recently reported the design and synthesis of poly(sebacoyl diglyceride) (PSeD) carrying a free hydroxyl group in its repeating unit. This paper examines the use of this polymer to promote biomineralization for application in bone tissue engineering. PSeD promoted more mineralization of extracellular matrix secreted by human mesenchymal stem cells and rat osteoblasts than poly(lactic-co-glycolic acid) (PLGA), which is currently widely used in bone tissue engineering. PSeD showed in vitro osteocompatibility and in vivo biocompatibility that matched or surpassed that of PLGA, as well as supported the attachment, proliferation and differentiation of rat osteoblasts and human mesenchymal stem cells. This demonstrates the potential of PSeD for use in bone regeneration.
功能基团可以控制生物界面，为治疗材料的制备提供了一种简单的方法。我们最近报道了一种在重复单元中携带游离羟基的聚（癸二酸二甘油酯）（PSeD）的设计和合成。本文研究了该聚合物在促进生物矿化方面的应用，以用于骨组织工程。与目前广泛应用于骨组织工程的聚（乳酸-共-羟基乙酸）（PLGA）相比，PSeD 促进了人骨髓间充质干细胞和大鼠成骨细胞分泌的细胞外基质的更多矿化。PSeD 表现出与 PLGA相当或超过的体外骨相容性和体内生物相容性，并且支持大鼠成骨细胞和人骨髓间充质干细胞的附着、增殖和分化。这证明了 PSeD 在骨再生中的应用潜力。
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