Hay F G, Leonard R C
University Department of Clinical Oncology, Western General Hospital, Edinburgh.
Dis Markers. 1988 Mar;6(1):29-39.
The patterns of reactivity of the monoclonal antibodies HMFG1 and HMFG2 were studied in epithelial ovarian tumours, small cell lung cancer, and non-small cell lung cancer. Twenty primary, paraffin embedded, ovarian tumours were analysed in addition to freshly obtained ascitic fluids (21), a node aspirate (1), solid metastatic tumours (3), and 6 established cell lines. SCLC tumours comprised paraffin embedded bronchial biopsies (31) and metastatic deposits (7) and fresh tissue from bronchial biopsies (3), pleural aspirates (4), bone marrows (5), node aspirates (6), solid metastatic tumour (3), and 4 cultured cell lines. Antigen expression was heterogeneous for all tumour types studied. However, significant differences in antigen expression were noted with the HMFG2 antibody between primary and metastatic lesions from both ovarian and small cell lung cancer groups.
对单克隆抗体HMFG1和HMFG2在上皮性卵巢肿瘤、小细胞肺癌和非小细胞肺癌中的反应模式进行了研究。除了新鲜获得的腹水（21份）、淋巴结穿刺液（1份）、实性转移瘤（3份）和6个已建立的细胞系外，还分析了20例原发性石蜡包埋的卵巢肿瘤。小细胞肺癌肿瘤包括石蜡包埋的支气管活检标本（31份）和转移灶（7份）以及支气管活检的新鲜组织（3份）、胸腔穿刺液（4份）、骨髓（5份）、淋巴结穿刺液（6份）、实性转移瘤（3份）和4个培养细胞系。在所研究的所有肿瘤类型中，抗原表达均呈异质性。然而，在卵巢癌和小细胞肺癌组的原发性和转移性病变之间，HMFG2抗体的抗原表达存在显著差异。
