Nilius Bernd, Carbone Emilio
Department of Cellular and Molecular Medicine, Laboratory Ion Channel Research, KU Leuven, Campus Gasthuisberg, Herestraat 49, bus 802, Leuven, Belgium.
Pflugers Arch. 2014 Apr;466(4):623-6. doi: 10.1007/s00424-014-1481-7. Epub 2014 Feb 25.
T-type Ca(2+) channels have gained, 15 years after cloning, an immense interest as novel players in very unexpected cell functions, and its many relations to diseases have been discovered. This special issue provides a state-of-the-art overview on novel functional properties of T-type Ca(2+) channels, unexpected cellular functions, and most importantly will also summarizes and review the involvement of this "tiny, transient" type of Ca(2+) channels in several diseases. It is tried to bridge the gap between molecular biophysical properties of T-type Ca(2+) channels and diseases providing finally a translational view on this amazing ion channel.
T型Ca(2+)通道在克隆15年后，作为新型参与者在非常意想不到的细胞功能中引起了极大关注，并且其与疾病的诸多关系也已被发现。本期特刊提供了关于T型Ca(2+)通道新功能特性、意想不到的细胞功能的最新综述，最重要的是还将总结和回顾这种“微小、短暂”的Ca(2+)通道在几种疾病中的作用。试图弥合T型Ca(2+)通道的分子生物物理特性与疾病之间的差距，最终提供关于这种惊人离子通道的转化观点。
