循环系统中的测量科学。
Measurement science in the circulatory system.
作者信息
Jones Casey M, Baker-Groberg Sandra M, Cianchetti Flor A, Glynn Jeremy J, Healy Laura D, Lam Wai Yan, Nelson Jonathan W, Parrish Diana C, Phillips Kevin G, Scott-Drechsel Devon E, Tagge Ian J, Zelaya Jaime E, Hinds Monica T, McCarty Owen J T
机构信息
Department of Biomedical Engineering, Oregon Health & Science University, Portland OR ; Department of Chemistry, Lewis & Clark College, Portland OR.
Department of Biomedical Engineering, Oregon Health & Science University, Portland OR.
出版信息
Cell Mol Bioeng. 2014 Mar;7(1):1-14. doi: 10.1007/s12195-013-0317-4.
The dynamics of the cellular and molecular constituents of the circulatory system are regulated by the biophysical properties of the heart, vasculature and blood cells and proteins. In this review, we discuss measurement techniques that have been developed to characterize the physical and mechanical parameters of the circulatory system across length scales ranging from the tissue scale (centimeter) to the molecular scale (nanometer) and time scales of years to milliseconds. We compare the utility of measurement techniques as a function of spatial resolution and penetration depth from both a diagnostic and research perspective. Together, this review provides an overview of the utility of measurement science techniques to study the spatial systems of the circulatory system in health and disease.
循环系统的细胞和分子成分的动态变化受心脏、血管系统以及血细胞和蛋白质的生物物理特性调控。在本综述中，我们讨论了已开发出的测量技术，这些技术用于表征循环系统在从组织尺度（厘米）到分子尺度（纳米）的长度范围内以及从数年到毫秒的时间尺度上的物理和机械参数。我们从诊断和研究的角度比较了测量技术作为空间分辨率和穿透深度函数的实用性。本综述共同提供了测量科学技术在研究健康和疾病状态下循环系统空间系统方面的实用性概述。
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