International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan 70101, Taiwan.
Department of Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan.
Cells. 2019 Aug 21;8(9):942. doi: 10.3390/cells8090942.
Mechanics in the human body are required for normal cell function at a molecular level. It is now clear that mechanical stimulations play significant roles in cell growth, differentiation, and migration in normal and diseased cells. Recent studies have led to the discovery that normal and cancer cells have different mechanosensing properties. Here, we discuss the application and the physiological and pathological meaning of mechanical stimulations. To reveal the optimal conditions for mimicking an in vivo microenvironment, we must, therefore, discern the mechanotransduction occurring in cells.
人体中的力学对于分子水平的正常细胞功能是必需的。现在很清楚，机械刺激在正常和患病细胞的细胞生长、分化和迁移中起着重要作用。最近的研究发现，正常细胞和癌细胞具有不同的机械感知特性。在这里，我们讨论了机械刺激的应用及其生理和病理意义。因此，为了揭示模拟体内微环境的最佳条件，我们必须辨别细胞中发生的机械转导。
