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玻璃体内单次注射曲安奈德治疗视网膜分支静脉阻塞继发黄斑水肿后对比敏感度的评估

Evaluation of contrast sensitivity after single intravitreal triamcinolone injection for macular edema secondary to branch retinal vein occlusion.

作者信息

Aras Ogreden Tulin, Alkin Zeynep, Ozkaya Abdullah, Ibrahim Demirkale Halil, Perente Irfan, Aras Cengiz

机构信息

Suleymaniye Women Health Hospital, Istanbul, Turkey.

Beyoglu Eye Training and Research Hospital, Bereketzade Cami Sok No. 2, Beyoglu, Istanbul, Turkey.

出版信息

ISRN Ophthalmol. 2013 Oct 3;2013:549240. doi: 10.1155/2013/549240. eCollection 2013.

Abstract

Purpose. To evaluate visual acuity (VA), contrast sensitivity (CS), and central retinal thickness (CRT) after intravitreal triamcinolone acetonide (IVT) injection for macular edema secondary to branch retinal vein occlusion (BRVO). Methods. In this prospective study, a total of 21 eyes of 21 patients were included. VA, CS, and CRT were assessed at baseline and at 1, 3, and 6 months after a single IVT injection. Results. Mean age was 64.57 ± 8.34 years. The mean baseline VA (LogMAR) increased from 1.11 ± 0.63 to 0.55 ± 0.39 (P < 0.001), 0.60 ± 0.40 (P < 0.001), and 0.78 ± 0.39 (P = 0.07) at 1, 3, and 6 months, respectively. The mean baseline CS (log CS) at 1 meter improved from 0.66 ± 0.49 to 1.11 ± 0.32 (P < 0.001), 0.99 ± 0.38 (P < 0.001), and 0.72 ± 0.37 (P = 0.8) at 1, 3, and 6 months, respectively. The mean baseline CS (log CS) at 3 meters improved from 0.34 ± 0.41 to 0.74 ± 0.41 (P < 0.001), 0.64 ± 0.44 (P = 0.036), and 0.46 ± 0.49 (P = 0.8) at 1, 3, and 6 months, respectively. The mean baseline CRT decreased from 511 ± 146 μm to 242 ± 119 μm, 277 ± 131 μm, and 402 ± 166 μm at 1, 3, and 6 months after IVT (P < 0.001 for each). Conclusion. Single IVT injection improved VA and CS and reduced CRT at 1 and 3 months of treatment. VA and CS returned to baseline levels at 6 months.

摘要

目的。评估玻璃体内注射曲安奈德(IVT)治疗视网膜分支静脉阻塞(BRVO)继发黄斑水肿后的视力(VA)、对比敏感度(CS)和中心视网膜厚度(CRT)。方法。在这项前瞻性研究中,共纳入了21例患者的21只眼。在单次IVT注射后的基线以及1、3和6个月时评估VA、CS和CRT。结果。平均年龄为64.57±8.34岁。平均基线视力(LogMAR)在1、3和6个月时分别从1.11±0.63提高到0.55±0.39(P<0.001)、0.60±0.40(P<0.001)和0.78±0.39(P = 0.07)。1米处的平均基线对比敏感度(log CS)在1、3和6个月时分别从0.66±0.49提高到1.11±0.32(P<0.001)、0.99±0.38(P<0.001)和0.72±0.37(P = 0.8)。3米处的平均基线对比敏感度(log CS)在1、3和6个月时分别从0.34±0.41提高到0.74±0.41(P<0.001)、0.64±0.44(P = 0.036)和0.46±0.49(P = 0.8)。IVT注射后1、3和6个月时,平均基线CRT分别从511±146μm降至242±119μm、277±131μm和402±166μm(每次P<0.001)。结论。单次IVT注射在治疗1和3个月时改善了VA和CS,并降低了CRT。VA和CS在6个月时恢复到基线水平。

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