Navarro Fernando, Pearson Deborah A, Fatheree Nicole, Mansour Rosleen, Hashmi S Shahrukh, Rhoads J Marc
Nutr Neurosci. 2015 May;18(4):177-85. doi: 10.1179/1476830514Y.0000000110. Epub 2014 Feb 12.
Studies have suggested a link between diet and behavior in children with autism spectrum disorders (ASDs). Parental reports of behavioral changes upon exposure to gluten and/or casein are common in clinical practice. An association between diet type, intestinal permeability (IP) ('leaky gut'), and behavior has been long proposed but not substantiated. We explored this possible association in this trial.
This randomized double-blind, placebo-controlled study explored the effects of gluten and milk on IP and behavior in children with ASDs over a period of 4 weeks. IP assessed by lactulose:mannitol (L/M) sugar permeability test and behavior assessed by the Aberrant Behavior Checklist and Conners Parent Rating were measured. Gastrointestinal symptoms in both groups were also monitored.
Neither the L/M ratio nor behavioral scores were different between groups exposed to gluten/dairy or placebo. The changes observed were noted to be small and not clinically significant.
Our study although underpowered to show small differences does not support an association between dietary gluten/milk, IP, and behavioral changes in subjects with ASD.
研究表明自闭症谱系障碍（ASD）儿童的饮食与行为之间存在联系。在临床实践中，家长报告孩子接触麸质和/或酪蛋白后行为发生变化的情况很常见。长期以来，人们一直认为饮食类型、肠道通透性（IP）（“肠漏”）与行为之间存在关联，但尚未得到证实。我们在本试验中探讨了这种可能的关联。
这项随机双盲、安慰剂对照研究在4周时间内，探究了麸质和牛奶对ASD儿童的IP和行为的影响。通过乳果糖：甘露醇（L/M）糖通透性试验评估IP，通过异常行为检查表和康纳斯父母评定量表评估行为。同时监测两组的胃肠道症状。
接触麸质/乳制品组和安慰剂组之间的L/M比值和行为评分均无差异。观察到的变化很小，且无临床意义。
我们的研究虽然不足以显示微小差异，但不支持饮食中的麸质/牛奶、IP与ASD受试者行为变化之间存在关联。
