Li Y, Zhang C, Song T
Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, China.
Physiol Res. 2014;63(3):377-85. doi: 10.33549/physiolres.932594. Epub 2014 Feb 24.
Extremely low-frequency magnetic field (ELF-MF) has been suggested to influence the cognitive capability but this should be dynamically evaluated in a longitudinal study. Previous training can affect performance, but the influence under magnetic field is unclear. This study aims to evaluate the effects of previous training and ELF-MF exposure on learning and memory using the Morris water maze (MWM). Sprague-Dawley rats were subjected to MWM training, ELF-MF exposure (50 Hz, 100 microT), or ELF-MF exposure combined with MWM training for 90 days. Normal rats were used as controls. The MWM was used to test. The data show that the rats exposed to training and ELF-MF with training performed better on spatial acquisition when re-tested. However, during the probe trial the rats showed no change between the training phase and the test phase. Compared with the control group, the ELF-MF group showed no significant differences. These results confirm that previous training can improve the learning and memory capabilities regarding spatial acquisition in the MWM and this effect can last for at least 90 days. However, this improvement in learning and memory capabilities was not observed during the probe trial. Furthermore, ELF-MF exposure did not interfere with the improvement in learning and memory capabilities.
极低频磁场（ELF-MF）被认为会影响认知能力，但这需要在纵向研究中进行动态评估。先前的训练会影响表现，但磁场作用下的影响尚不清楚。本研究旨在使用莫里斯水迷宫（MWM）评估先前训练和ELF-MF暴露对学习和记忆的影响。将斯普拉格-道利大鼠进行MWM训练、ELF-MF暴露（50赫兹，100微特斯拉）或ELF-MF暴露联合MWM训练，持续90天。正常大鼠作为对照。使用MWM进行测试。数据显示，接受训练和接受训练同时暴露于ELF-MF的大鼠在重新测试时在空间获取方面表现更好。然而，在探索试验期间，大鼠在训练阶段和测试阶段之间没有变化。与对照组相比，ELF-MF组没有显著差异。这些结果证实，先前的训练可以提高MWM中空间获取方面的学习和记忆能力，并且这种效果可以持续至少90天。然而，在探索试验期间未观察到学习和记忆能力的这种改善。此外，ELF-MF暴露并未干扰学习和记忆能力的提高。
