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剖宫产术前使用咪达唑仑进行预处理对新生儿无不良影响。

Premedication with midazolam prior to caesarean section has no neonatal adverse effects.

作者信息

Senel Ahmet Can, Mergan Fatih

机构信息

Department of Anesthesiology and Critical Care, School of Medicine, Karadeniz Technical University, Trabzon, Turkey.

Department of Anesthesiology and Critical Care, School of Medicine, Karadeniz Technical University, Trabzon, Turkey.

出版信息

Braz J Anesthesiol. 2014 Jan-Feb;64(1):16-21. doi: 10.1016/j.bjane.2012.08.005. Epub 2013 Dec 11.

DOI:10.1016/j.bjane.2012.08.005
PMID:24565384
Abstract

Like all surgical patients, obstetric patients also feel operative stress and anxiety. This can be prevented by giving patients detailed information about their operation and with preoperative pharmacological medications. Because of depressive effects of sedatives on newborns, pharmacological medications are omitted, especially in obstetric patients. The literature contains few studies concerning preoperative midazolam use in Caesarian section (C/S) patients. Our aim in this study was to help patients undergoing C/S surgery. One group scheduled for elective C/S received midazolam 0.025 mg kg(-1) intravenously, the other received saline. Maternal anxiety was evaluated using Amsterdam Preoperative Anxiety and Information Scale (APAIS) scores, and newborns were evaluated using Apgar and the Neonatal Neurologic and Adaptive Capacity Score (NACS). In conclusion, patients receiving midazolam 0.025 mg kg(-1) as premedication had significantly low anxiety scores, without any adverse effects on the newborns. Midazolam can therefore safely be used as a premedicative agent in C/S surgery.

摘要

与所有外科手术患者一样,产科患者也会感到手术压力和焦虑。这可以通过向患者提供有关其手术的详细信息以及术前使用药物来预防。由于镇静剂对新生儿有抑制作用,因此不使用药物,尤其是在产科患者中。关于剖宫产(C/S)患者术前使用咪达唑仑的研究文献很少。我们这项研究的目的是帮助接受C/S手术的患者。一组计划进行择期C/S的患者静脉注射0.025 mg kg(-1)的咪达唑仑,另一组接受生理盐水。使用阿姆斯特丹术前焦虑和信息量表(APAIS)评分评估产妇焦虑,使用阿普加评分和新生儿神经与适应能力评分(NACS)评估新生儿。总之,术前接受0.025 mg kg(-1)咪达唑仑的患者焦虑评分显著降低,且对新生儿无任何不良影响。因此,咪达唑仑可安全地用作C/S手术的术前用药。

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Premedication with midazolam prior to caesarean section has no neonatal adverse effects.剖宫产术前使用咪达唑仑进行预处理对新生儿无不良影响。
Braz J Anesthesiol. 2014 Jan-Feb;64(1):16-21. doi: 10.1016/j.bjane.2012.08.005. Epub 2013 Dec 11.
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