Quan Ning
Institute for Behavior Medicine Research, The Ohio State University, Columbus, OH 43210, USA.
Brain Behav Immun. 2014 Aug;40:1-8. doi: 10.1016/j.bbi.2014.02.006. Epub 2014 Feb 22.
Since my last review on neuroimmune communication afferents in 2008, this area has witnessed substantial growth. At a basic science level, numerous new and exciting phenomena have been described, adding both depth and complexity to the crosstalk between the immune system and the nervous system. At a translational level, accumulating evidence indicates neuroimmune interaction could be a contributing factor for many disease states, as well as an effective physiological mechanism that coordinates the activities of these two systems in healthy individuals or during tissue distress. Furthermore, new evidence suggests neuroimmune interactions are inherently dynamic: varying activities in either the nervous system or the immune system could impact interactions between them. In this review I will attempt to integrate multifarious, and sometimes disparate, findings into a modified conceptual framework that describes the concordance of neuroimmune communication through the cooperative connection between these two systems and the dysfunction that may arise when their inappropriate crosstalk occurs.
自2008年我上次对神经免疫通讯传入神经进行综述以来，该领域取得了显著发展。在基础科学层面，已描述了众多新奇有趣的现象，为免疫系统与神经系统之间的相互作用增添了深度与复杂性。在转化医学层面，越来越多的证据表明，神经免疫相互作用可能是多种疾病状态的一个促成因素，也是在健康个体或组织受损时协调这两个系统活动的一种有效生理机制。此外，新证据表明神经免疫相互作用本质上是动态的：神经系统或免疫系统中活动的变化都可能影响它们之间的相互作用。在本综述中，我将尝试把各种各样、有时甚至是不同的研究结果整合到一个经过修改的概念框架中，该框架描述了通过这两个系统之间的协同连接实现的神经免疫通讯的一致性，以及当它们发生不适当的相互作用时可能出现的功能障碍。
