Division of Basic Reproductive Sciences, University of Colorado School of Medicine, Mail Stop 8613, 12700 E. 19th Ave., Aurora, CO, 80045, USA,
J Mammary Gland Biol Neoplasia. 2014 Mar;19(1):35-42. doi: 10.1007/s10911-014-9318-8. Epub 2014 Feb 25.
Mammalian cells depend on phospholipid (PL) and fatty acid (FA) transport to maintain membrane structure and organization, and to fuel and regulate cellular functions. In mammary glands of lactating animals, copious milk secretion, including large quantities of lipid in some species, requires adaptation and integration of PL and FA synthesis and transport processes to meet secretion demands. At present few details exist about how these processes are regulated within the mammary gland. However, recent advances in our understanding of the structural and molecular biology of membrane systems and cellular lipid trafficking provide insights into the mechanisms underlying the regulation and integration of PL and FA transport processes the lactating mammary gland. This review discusses the PL and FA transport processes required to maintain the structural integrity and organization of the mammary gland and support its secretory functions within the context of current molecular and cellular models of their regulation.
哺乳动物细胞依赖于磷脂 (PL) 和脂肪酸 (FA) 的运输来维持膜结构和组织，并为细胞功能提供燃料和调节。在泌乳动物的乳腺中，大量的乳汁分泌，包括某些物种中的大量脂质，需要适应和整合 PL 和 FA 的合成和运输过程，以满足分泌需求。目前，关于这些过程在乳腺中是如何被调节的，我们知之甚少。然而，最近我们对膜系统和细胞脂质运输的结构和分子生物学的理解的进展，为理解调节和整合泌乳乳腺中 PL 和 FA 运输过程的机制提供了线索。本综述讨论了维持乳腺结构完整性和组织以及支持其分泌功能所需的 PL 和 FA 运输过程，同时还考虑了目前关于它们调节的分子和细胞模型。
