Onabajo Olusegun O, Mattapallil Joseph J
Department of Microbiology & Immunology, Uniformed Services University, Bethesda, MD 20814, USA.
Curr HIV Res. 2013 Dec;11(8):595-600. doi: 10.2174/1570162x12666140225153552.
HIV infection is characterized by aberrant B cell responses and B cell dysfunction. These dysfunctional responses have been extensively documented in peripheral blood and organized lymphoid tissues such as the lymph nodes. Though the loss of CD4 T cell help has been thought to play a key role in dysfunctional B cell responses, recent studies have implicated a subset of CD4 T helper cells called the T follicular helper (Tfh) cells in this process. Tfh cells interact with B cells and play a key role in mediating the germinal center reaction, and driving the differentiation and maturation of B cells. Why Tfh expands in some HIV infected individuals as compared to their loss in others is still not clear. Here we review some of the recent developments in the field and discuss the implications of Tfh cell dysregulation on B cell responses during HIV infection.
HIV感染的特征是B细胞反应异常和B细胞功能障碍。这些功能失调的反应在外周血和有组织的淋巴组织如淋巴结中已有广泛记录。尽管人们认为CD4 T细胞辅助功能的丧失在功能失调的B细胞反应中起关键作用，但最近的研究表明，在此过程中一种称为滤泡辅助性T（Tfh）细胞的CD4 T辅助细胞亚群也与之相关。Tfh细胞与B细胞相互作用，在介导生发中心反应以及驱动B细胞的分化和成熟中起关键作用。与其他HIV感染者中Tfh细胞减少相比，为何在一些HIV感染者中Tfh细胞会扩增，目前仍不清楚。在此，我们综述该领域的一些最新进展，并讨论HIV感染期间Tfh细胞失调对B细胞反应的影响。
