5-氨基酮戊酸光动力疗法与红光治疗光老化的比较。
Comparison of 5-aminolevulinic acid photodynamic therapy and red light for treatment of photoaging.
机构信息
Shanghai Skin Diseases Hospital, Shanghai, China.
Department of Dermatology, Huadong Hospital, Shanghai, China.
出版信息
Photodiagnosis Photodyn Ther. 2014 Jun;11(2):118-21. doi: 10.1016/j.pdpdt.2014.02.007. Epub 2014 Feb 23.
OBJECTIVE
The aim of this pilot study was to compare the efficacy of ALA-PDT and red light alone in the treatment of photoaging.
METHODS
A total of 14 adults with photoaging skin were recruited. ALA-PDT or red light alone was applied to the forearm extensor. Before and after treatment, the treated sites were examined by dermoscopy, the changes in straum corneum (SC) hydration, transepidermal water loss (TEWL), and the Lab* values were measured, and microscopic examination of collagens and elastins was performed.
RESULTS
After ALA-PDT or red light illumination, the appearance of photoaging lesions improved, SC hydration increased and TEWL decreased. These changes in the ALA-PDT group were more obvious than those in the red light group. No significant change was noticed in the Lab* values in both groups. The signs of typical solar elastosis damage were improved in both groups.
CONCLUSIONS
ALA-PDT showed better skin rejuvenation effect than red light alone.
目的
本初步研究旨在比较 ALA-PDT 和单纯红光单独治疗光老化的疗效。
方法
共招募 14 名光老化皮肤的成年人。将 ALA-PDT 或单纯红光应用于前臂伸肌。治疗前后，通过皮肤镜检查治疗部位，测量角质层（SC）水分、经皮水分丢失（TEWL）和 Lab*值的变化，并对胶原纤维和弹性纤维进行显微镜检查。
结果
ALA-PDT 或红光照射后，光老化病变的外观改善，SC 水分增加，TEWL 降低。ALA-PDT 组的这些变化比红光组更明显。两组的 Lab*值均无明显变化。两组的典型日光弹性纤维变性损伤征象均得到改善。
结论
ALA-PDT 显示出比单纯红光更好的皮肤年轻化效果。
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