Department of Dermatology, West China Hospital of Sichuan University, Chengdu, Sichuan,610041,China; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA.
Department of Dermatology, West China Hospital of Sichuan University, Chengdu, Sichuan,610041,China.
Photodiagnosis Photodyn Ther. 2017 Sep;19:140-152. doi: 10.1016/j.pdpdt.2017.06.010. Epub 2017 Jun 21.
Photodynamic therapy (PDT) employs a photosensitizer (PS) and visible light in the presence of oxygen, leading to production of cytotoxic reactive oxygen species, which can damage the cellular organelles and cause cell death. In dermatology, PDT has usually taken the form of topical application of a precursor in the heme biosynthesis pathway, called 5-aminolevulinic acid (or its methyl ester), so that an active PS, protoporphyrin IX accumulates in the skin. As PDT enhances dermal remodeling and resolves chronic inflamation, it has been used to treat cutaneous disorders include actinic keratoses, acne, viral warts, skin rejuvenation, psoriasis, localized scleroderma, some non-melanoma skin cancers and port-wine stains. Efforts are still needed to mitigate the side effects (principally pain) and improve the overall procedure.
光动力疗法（PDT）利用光敏剂（PS）和可见光在氧气存在的情况下，产生细胞毒性活性氧物质，这些物质可以破坏细胞器官并导致细胞死亡。在皮肤病学中，PDT 通常采用在血红素生物合成途径中局部应用前体的形式，称为 5-氨基酮戊酸（或其甲酯），以便在皮肤中积累活性 PS，原卟啉 IX。由于 PDT 增强了真皮重塑并解决了慢性炎症，因此它已被用于治疗包括光化性角化病、痤疮、病毒性疣、皮肤年轻化、银屑病、局限性硬皮病、某些非黑色素瘤皮肤癌和葡萄酒色斑在内的皮肤疾病。仍需要努力减轻副作用（主要是疼痛）并改善整体治疗过程。
