Shanghai Skin Diseases Hospital, Shanghai 200050, China.
MOE Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Normal University, Fuzhou, China.
Photodiagnosis Photodyn Ther. 2014 Dec;11(4):498-509. doi: 10.1016/j.pdpdt.2014.10.003. Epub 2014 Oct 23.
To evaluate the outcomes of the combination of red light or intense pulsed laser (IPL) with 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) in the treatment of photodamaged neck skin.
The anterior of the neck was divided into four 2 cm × 2 cm sections and randomly assigned to red-light, red-light-PDT, IPL or IPL-PDT group. ALA cream of 5% was applied to PDT regions for 2h prior to light irradiation. Treatment was repeated once. The stratum corneum (SC) hydration, transepidermal water loss (TEWL), L(), a(), b(*) values, melanin index (MI), erythema index (EI), skin elasticity and skin thickness were examined by a blinded investigator. The function and volume of thyroid were also measured.
After red-light-PDT, IPL-PDT and IPL treatment, the appearance of photoaging lesion was improved. The SC hydration, L() value, elasticity and thickness increased, whereas the TEWL and MI value decreased. These changes in red-light-PDT and IPL-PDT group were more obvious than IPL group. The a() and EI value increased in red-light-PDT group. No significant change was noticed in red-light group. Partial irradiation of the thyroid did not affect the function and volume of the thyroid.
IPL-PDT and red-light-PDT showed better rejuvenation effect than IPL or red light alone on the neck skin.
评估红光或强脉冲光（IPL）联合 5-氨基酮戊酸（ALA）介导光动力疗法（PDT）治疗光损伤颈部皮肤的疗效。
将颈部前部分为四个 2cm×2cm 的区域，随机分为红光、红光-PDT、IPL 或 IPL-PDT 组。在光照射前 2h 将 5%ALA 乳膏应用于 PDT 区域。治疗重复一次。由一位盲法观察者评估角质层（SC）水合作用、经表皮水分丢失（TEWL）、L值、a值、b*值、黑色素指数（MI）、红斑指数（EI）、皮肤弹性和皮肤厚度。还测量了甲状腺的功能和体积。
在红光-PDT、IPL-PDT 和 IPL 治疗后，光老化病变的外观得到改善。SC 水合作用、L值、弹性和厚度增加，而 TEWL 和 MI 值降低。与 IPL 组相比，红光-PDT 和 IPL-PDT 组的这些变化更为明显。红光-PDT 组 a和 EI 值增加，红光组无明显变化。甲状腺的部分照射对甲状腺的功能和体积没有影响。
与 IPL 或红光单独治疗相比，IPL-PDT 和红光-PDT 对颈部皮肤具有更好的年轻化效果。
