Yamazaki Shin, Shima Masayuki, Nakadate Toshio, Ohara Toshimasa, Omori Takashi, Ono Masaji, Sato Tosiya, Nitta Hiroshi
Center for Environmental Health Sciences, National Institute for Environmental Studies, Tsukuba, Japan.
Int Arch Allergy Immunol. 2015;167(4):253-63. doi: 10.1159/000439534. Epub 2015 Oct 2.
This study clarified sensitization patterns to house dust mite (HDM) and Japanese cedar pollen (JCP) in Japanese lower-grade schoolchildren. We also explored factors associated with allergic sensitization.
This cross-sectional study used a database from the Study on Respiratory Disease and Automobile Exhaust (SORA), a Japanese health study project. The subjects comprised 8,815 pupils aged 6-9 years. We obtained the distribution of HDM- and JCP-specific IgE, respectively, as a marker of sensitization. To determine factors associated with sensitization, we used logistic regression and calculated adjusted odds ratios (AORs) for the relative prevalence of sensitization. The cut-off point for specific IgE levels was 0.35 kU/l.
Sensitization to HDM and JCP was detected in 51 and 39% of subjects, respectively, occurring more often in boys and at older ages. In addition, AORs of sensitization to HDM/JCP were higher in subjects with a history of bronchitis, parental asthma, parental atopic eczema and parental pollinosis. In contrast, AORs for sensitization were lower in those subjected to maternal passive smoking as well as among boys with pets. AORs of sensitization to JCP alone were lower in those with a history of otitis media, those who had been bottle milk fed, and those who were not the firstborn and who lived near a busy road.
Sensitization to HDM and JCP was detected in 51 and 39% of lower-grade schoolchildren, respectively.
本研究阐明了日本低年级学童对屋尘螨（HDM）和日本雪松花粉（JCP）的致敏模式。我们还探讨了与过敏致敏相关的因素。
这项横断面研究使用了日本健康研究项目“呼吸系统疾病与汽车尾气研究（SORA）”的数据库。研究对象包括8815名6 - 9岁的小学生。我们分别获取了HDM特异性IgE和JCP特异性IgE的分布情况，作为致敏的标志物。为了确定与致敏相关的因素，我们使用逻辑回归分析，并计算了致敏相对患病率的调整比值比（AORs）。特异性IgE水平的截断点为0.35 kU/l。
分别在51%和39%的研究对象中检测到对HDM和JCP的致敏，男孩和年龄较大的儿童中更为常见。此外，有支气管炎病史、父母患有哮喘、父母患有特应性皮炎以及父母患有花粉症的研究对象对HDM/JCP致敏的AORs更高。相比之下，遭受母亲被动吸烟的儿童以及养宠物的男孩致敏的AORs更低。单独对JCP致敏的AORs在有中耳炎病史、曾用奶瓶喂养、非头胎且居住在繁忙道路附近的儿童中更低。
分别在51%和39%的低年级学童中检测到对HDM和JCP的致敏。
