Department of Ophthalmology, Asan Medical Center, Division of Biostatistics, Center for Medical Research and Information, University of Ulsan, College of Medicine, Seoul, Korea.
Invest Ophthalmol Vis Sci. 2014 Apr 7;55(4):2148-56. doi: 10.1167/iovs.13-13607.
To characterize the circadian pattern of habitual-position intraocular pressure (IOP) and its association with ocular dimension in young myopic patients with open-angle glaucoma (OAG).
A total of 108 young OAG patients with moderate to severe myopia (myopia group) and 67 age-matched OAG patients with emmetropia or mild myopia (control group) were recruited prospectively over 3 years. IOP was recorded 11 times over a 24-hour period by a single, well-trained ophthalmology resident using a handheld tonometer.
A total of 87 men and 88 women were included in this study. Analysis of the entire myopia group indicated no acrophase in habitual-position IOP over 24 hours. Subgroup analysis indicated that 44 patients (40.7%) had a diurnal acrophase, 17 patients (15.7%) had a nocturnal acrophase, and 47 patients (43.6%) had no evident acrophase. By contrast, the control group showed an overall nocturnal acrophase in habitual-position IOP, with 14 patients (20.8%) having a diurnal acrophase, 30 patients (44.8%) having a nocturnal acrophase, and 23 patients (34.4%) having no evident acrophase in subgroup analysis. There was a negative correlation between nocturnal habitual-position IOP elevation and axial length in the overall population.
In young myopic OAG eyes, there is no significant nocturnal elevation in habitual-position IOP, while IOP increases at night-time in age-matched control eyes. The overall 24-hour IOP pattern in the myopia group did not show an acrophase. Finally, data showed a negative relationship between nocturnal habitual-position IOP elevation and axial length.
描述年轻近视开角型青光眼（OAG）患者习惯性体位眼压（IOP）的昼夜节律特征及其与眼球尺寸的关系。
前瞻性纳入 3 年中患有中重度近视的 108 例年轻 OAG 近视患者（近视组）和 67 例年龄匹配的正视或轻度近视的 OAG 患者（对照组）。由一位训练有素的眼科住院医师使用手持眼压计在 24 小时内记录 11 次 IOP。
本研究共纳入 87 名男性和 88 名女性。对整个近视组的分析表明，24 小时内习惯性体位 IOP 无高峰值。亚组分析表明，44 例（40.7%）患者存在昼夜高峰值，17 例（15.7%）患者存在夜间高峰值，47 例（43.6%）患者无明显高峰值。相比之下，对照组的习惯性体位 IOP 总体呈夜间高峰值，14 例（20.8%）患者有昼夜高峰值，30 例（44.8%）患者有夜间高峰值，23 例（34.4%）患者无明显高峰值。总体人群中，夜间习惯性体位 IOP 升高与眼轴长度呈负相关。
在年轻近视性 OAG 眼中，习惯性体位 IOP 无明显夜间升高，而年龄匹配的对照组眼中 IOP 在夜间增加。近视组的整体 24 小时 IOP 模式没有表现出高峰值。最后，数据显示夜间习惯性体位 IOP 升高与眼轴长度呈负相关。
