Blankenhorn E P, Duncan R, Huppi K, Potter M
Department of Microbiology and Immunology, Hahnemann University, Philadelphia, Pennsylvania 19102-1192.
Genetics. 1988 Jul;119(3):687-91. doi: 10.1093/genetics/119.3.687.
Afr-1 is a gene whose product contributes to the adult regulation of mouse alpha-fetoprotein (AFP). In Afr-1b/b homozygotes, the adult serum levels of AFP are 10- to 20-fold higher than in Afr-1a/a or Afr-1a/b mice. The studies reported here were performed to map the Afr-1 gene. Our results show that Afr-1 resides on mouse chromosome 15, approximately 25 cM from Gdc-1. Afr-1 appears to be located in close proximity to the mouse c-myc oncogene. These results are discussed with respect to the susceptibility or resistance of different BALB/c sublines (which are either Afr-1a or Afr-1b, respectively) to pristane-induced plasmacytomas.
Afr-1是一个基因，其产物有助于成年小鼠甲胎蛋白（AFP）的调节。在Afr-1b/b纯合子中，成年小鼠血清中AFP的水平比Afr-1a/a或Afr-1a/b小鼠高10至20倍。本文报道的研究旨在对Afr-1基因进行定位。我们的结果表明，Afr-1位于小鼠15号染色体上，距离Gdc-1约25厘摩。Afr-1似乎紧邻小鼠c-myc癌基因。针对不同BALB/c亚系（分别为Afr-1a或Afr-1b）对 pristane诱导的浆细胞瘤的易感性或抗性对这些结果进行了讨论。
