Zeng Yingchun, Huang Meiling, Cheng Andy S K, Zhou Ying, So Winnie K W
Department of Obstetrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China,
Breast Cancer. 2014 May;21(3):262-74. doi: 10.1007/s12282-014-0521-7. Epub 2014 Feb 26.
Breast cancer is the most common type of cancer among women worldwide. Diagnosis and treatment of breast cancer pose an array of physical and psychological threats to the survivors. Exercise interventions may be particularly appropriate for cancer survivors because they have the potential to improve physical and psychological functioning. The review aims to examine the effectiveness of exercise intervention on the quality of life (QOL) of breast cancer survivors. Five databases (Medline, CINAHL, Scopus, The Cochrane Library, and CAJ Full-text Database) were searched from 2003 to July 2013. Clinical controlled trials of exercise interventions for breast cancer survivors who were at least 18 years old and had completed active cancer treatment were included. A total of 25 trials were included in this study, of which 19 were pooled together statistically. Subjects in the exercise interventions had higher overall QOL than subjects in the control group. The standardized mean difference (SMD) for changes in overall general QOL scores was 0.70 (95 % CI 0.21, 1.19). The SMD for changes in cancer-specific QOL scores was 0.38 (95 % CI 0.03, 0.74). For cancer-specific QOL domains, there were positive but non-significant trends in two QOL domains (breast symptoms: Z score = 1.12, p = 0.26; arm symptoms: Z score = 1.32, p = 0.19). This study provides updated findings supporting the idea that exercise interventions have statistically significant effects on overall QOL in breast cancer survivors, as well as positive trends for cancer site-specific QOL domains (breast and arm symptoms).
乳腺癌是全球女性中最常见的癌症类型。乳腺癌的诊断和治疗给幸存者带来了一系列身体和心理上的威胁。运动干预可能对癌症幸存者特别合适，因为它们有改善身体和心理功能的潜力。本综述旨在研究运动干预对乳腺癌幸存者生活质量（QOL）的有效性。检索了五个数据库（Medline、CINAHL、Scopus、Cochrane图书馆和中国学术期刊全文数据库），检索时间为2003年至2013年7月。纳入了针对至少18岁且已完成积极癌症治疗的乳腺癌幸存者的运动干预临床对照试验。本研究共纳入25项试验，其中19项进行了统计学合并。运动干预组的受试者总体生活质量高于对照组。总体一般生活质量得分变化的标准化平均差（SMD）为0.70（95%CI 0.21，1.19）。癌症特异性生活质量得分变化的SMD为0.38（95%CI 0.03，0.74）。对于癌症特异性生活质量领域，在两个生活质量领域（乳房症状：Z评分=1.12，p=0.26；手臂症状：Z评分=1.32，p=0.19）有积极但无统计学意义的趋势。本研究提供了最新的研究结果，支持运动干预对乳腺癌幸存者的总体生活质量有统计学显著影响，以及对癌症部位特异性生活质量领域（乳房和手臂症状）有积极趋势的观点。
