Murtezani Ardiana, Ibraimi Zana, Bakalli Aurora, Krasniqi Shaip, Disha Emine Devolli, Kurtishi Ilir
Department of Physical and Rehabilitation Medicine, University Clinical Center of Kosovo, Kosovo, .
J Cancer Res Ther. 2014 Jul-Sep;10(3):658-64. doi: 10.4103/0973-1482.137985.
To determine the effect of moderate-intensity aerobic exercise on the quality of life (QOL) and physical functioning in breast cancer survivors.
We randomly assigned 62 breast cancer survivors to an exercise (N = 30) or control group (N = 32). The exercise group trained at a moderate intensity progressing from 25 to 40 min over a 10-week period. The control group did not train. Outcomes were assessed at baseline and postintervention. The primary outcomes were overall QOL--as assessed by the functional assessment of cancer therapy-breast (FACT-B) scale. Secondary outcomes were changes in various subscales of overall QOL, and changes in body composition outcomes: body weight, body mass index, and changes in performance in a 12 min walk test (12MWT).
Sixty-two of 73 women randomized (84.9%) completed the study. There were no significant differences amongst the two groups at baseline for any variable. In the exercise group significant improvements were demonstrated for the FACT-B (13.4 points, P < 0.003), functional assessment of cancer therapy-general (FACT-G) (9.16 points, P < 0.008), the functional well-being subscale (P < 0.010), and the emotional well-being subscale (P < 0.035) compared to the control group. No significant changes in body weight or BMI were observed. Exercise group showed a significant increase in 12MWT (P < 0.009).
We conclude that 10 week of moderate-intensity aerobic exercise program significantly improves QOL and physical functioning in breast cancer survivors. Future studies are needed to evaluate the effectiveness of similar exercise programs over longer periods of time and involving a greater number of breast cancer survivors.
确定中等强度有氧运动对乳腺癌幸存者生活质量（QOL）和身体机能的影响。
我们将62名乳腺癌幸存者随机分为运动组（N = 30）和对照组（N = 32）。运动组在10周内进行中等强度训练，时长从25分钟逐渐增加至40分钟。对照组不进行训练。在基线期和干预后对结果进行评估。主要结果是通过癌症治疗功能评估-乳腺癌（FACT-B）量表评估的总体生活质量。次要结果是总体生活质量各个子量表的变化，以及身体成分指标的变化：体重、体重指数，以及12分钟步行测试（12MWT）表现的变化。
73名随机分组的女性中有62名（84.9%）完成了研究。两组在基线期的任何变量上均无显著差异。与对照组相比，运动组在FACT-B（13.4分，P < 0.003）、癌症治疗功能评估-通用版（FACT-G）（9.16分，P < 0.008）、功能健康子量表（P < 0.010）和情感健康子量表（P < 0.035）方面均有显著改善。未观察到体重或体重指数有显著变化。运动组在12MWT中表现出显著提高（P < 0.009）。
我们得出结论，为期10周的中等强度有氧运动计划可显著改善乳腺癌幸存者的生活质量和身体机能。未来需要进行研究，以评估类似运动计划在更长时间内对更多乳腺癌幸存者的有效性。
