Program in Cell and Molecular Biology, University of Arkansas, Fayetteville 72701.
Poult Sci. 2014 Feb;93(2):307-17. doi: 10.3382/ps.2013-03359.
A genome-wide SNP survey was used to identify chromosomal regions that showed linkage disequilibrium with respect to ascites susceptibility and ventricular hypertrophy in an F2 cross between previously described ascites-resistant and -susceptible lines. Variable number tandem repeats were used to obtain genotype data to further characterize these regions. A region on chromosome 9 (12 to 13 Mbp in 2011 assembly) shows association with ascites in the ascites lines and in several commercial broiler breeder lines with a significant sex effect. There are 2 candidate genes, AGTR1 (an angiotensin II type 1 receptor) and UTS2D (urotensin 2 domain containing), in this region that have been associated with hypertension and hypoxic response in mammals.
采用全基因组 SNP 调查，鉴定了与腹水易感性和心室肥大有关的染色体区域，这些区域在先前描述的腹水抗性和敏感性系之间的 F2 杂交中表现出连锁不平衡。利用可变数串联重复序列获得基因型数据，进一步描述这些区域。第 9 号染色体上的一个区域（2011 年组装的 12 到 13 Mbp）与腹水线中的腹水以及几个具有显著性别效应的商业肉鸡育种线中的腹水有关。该区域有 2 个候选基因，AGTR1（血管紧张素 II 型 1 受体）和 UTS2D（含尿抑素 2 域），它们与哺乳动物的高血压和低氧反应有关。
