肉鸡品系 9 号染色体腹水的数量性状位点。
A quantitative trait locus for ascites on chromosome 9 in broiler chicken lines.
机构信息
Program in Cell and Molecular Biology, University of Arkansas, Fayetteville 72701.
出版信息
Poult Sci. 2014 Feb;93(2):307-17. doi: 10.3382/ps.2013-03359.
Abstract
A genome-wide SNP survey was used to identify chromosomal regions that showed linkage disequilibrium with respect to ascites susceptibility and ventricular hypertrophy in an F2 cross between previously described ascites-resistant and -susceptible lines. Variable number tandem repeats were used to obtain genotype data to further characterize these regions. A region on chromosome 9 (12 to 13 Mbp in 2011 assembly) shows association with ascites in the ascites lines and in several commercial broiler breeder lines with a significant sex effect. There are 2 candidate genes, AGTR1 (an angiotensin II type 1 receptor) and UTS2D (urotensin 2 domain containing), in this region that have been associated with hypertension and hypoxic response in mammals.
摘要
采用全基因组 SNP 调查，鉴定了与腹水易感性和心室肥大有关的染色体区域，这些区域在先前描述的腹水抗性和敏感性系之间的 F2 杂交中表现出连锁不平衡。利用可变数串联重复序列获得基因型数据，进一步描述这些区域。第 9 号染色体上的一个区域（2011 年组装的 12 到 13 Mbp）与腹水线中的腹水以及几个具有显著性别效应的商业肉鸡育种线中的腹水有关。该区域有 2 个候选基因，AGTR1（血管紧张素 II 型 1 受体）和 UTS2D（含尿抑素 2 域），它们与哺乳动物的高血压和低氧反应有关。
相似文献
1
A quantitative trait locus for ascites on chromosome 9 in broiler chicken lines.肉鸡品系 9 号染色体腹水的数量性状位点。
Poult Sci. 2014 Feb;93(2):307-17. doi: 10.3382/ps.2013-03359.
2
Further investigation of a quantitative trait locus for ascites on chromosome 9 in broiler chicken lines.对肉鸡品系9号染色体上腹水症数量性状基因座的进一步研究。
Poult Sci. 2017 Apr 1;96(4):788-797. doi: 10.3382/ps/pew380.
3
Identification and validation of quantitative trait loci for ascites syndrome in broiler chickens using whole genome resequencing.利用全基因组重测序鉴定肉鸡腹水综合征的数量性状基因座并进行验证。
BMC Genet. 2020 May 20;21(1):54. doi: 10.1186/s12863-020-00859-x.
4
Effects of a chromosome 9 quantitative trait locus for ascites on economically important traits in broilers.9 号染色体腹水数量性状基因座对肉鸡经济重要性状的影响。
Poult Sci. 2017 Sep 1;96(9):3039-3042. doi: 10.3382/ps/pex154.
5
Predicting ascites incidence in a simulated altitude-challenge using single nucleotide polymorphisms identified in multi-generational genome wide association studies.利用多代全基因组关联研究中确定的单核苷酸多态性预测模拟海拔挑战中的腹水发生率。
Poult Sci. 2018 Nov 1;97(11):3801-3806. doi: 10.3382/ps/pey273.
6
Multi-generational genome wide association studies identify chromosomal regions associated with ascites phenotype.多代全基因组关联研究鉴定与腹水表型相关的染色体区域。
Poult Sci. 2017 Jun 1;96(6):1544-1552. doi: 10.3382/ps/pew478.
7
Metabolic rate and its relationship with ascites in chicken genotypes.鸡基因型中的代谢率及其与腹水的关系。
Br Poult Sci. 2003 May;44(2):309-15. doi: 10.1080/000716603100024603.
8
Single nucleotide polymorphism variants within tva and tvb receptor genes in Chinese chickens.中国鸡中tva和tvb受体基因内的单核苷酸多态性变体。
Poult Sci. 2014 Oct;93(10):2482-9. doi: 10.3382/ps.2014-04077. Epub 2014 Aug 14.
9
SNP-based breeding for broiler resistance to ascites and evaluation of correlated production traits.基于 SNP 的肉鸡腹水抗性选育及相关生产性状的评估。
Hereditas. 2022 Jan 28;159(1):9. doi: 10.1186/s41065-022-00228-x.
10
Performance and physiological variables in broiler chicken lines differing in susceptibility to the ascites syndrome: 1. Changes in blood gases as a function of ambient temperature.对腹水综合征易感性不同的肉鸡品系的生产性能和生理变量：1. 作为环境温度函数的血气变化
Br Poult Sci. 1999 Mar;40(1):135-9. doi: 10.1080/00071669987971.
引用本文的文献
1
SNP-based breeding for broiler resistance to ascites and evaluation of correlated production traits.基于 SNP 的肉鸡腹水抗性选育及相关生产性状的评估。
Hereditas. 2022 Jan 28;159(1):9. doi: 10.1186/s41065-022-00228-x.
2
Identification and validation of quantitative trait loci for ascites syndrome in broiler chickens using whole genome resequencing.利用全基因组重测序鉴定肉鸡腹水综合征的数量性状基因座并进行验证。
BMC Genet. 2020 May 20;21(1):54. doi: 10.1186/s12863-020-00859-x.
3
The comparative analysis of phenotypic and whole transcriptome gene expression data of ascites susceptible versus ascites resistant chickens.腹水易感性与腹水抗性鸡的表型和全转录组基因表达数据的比较分析。
Mol Biol Rep. 2019 Feb;46(1):793-804. doi: 10.1007/s11033-018-4534-8. Epub 2018 Dec 5.
4
Whole genome resequencing identifies the CPQ gene as a determinant of ascites syndrome in broilers.全基因组重测序确定CPQ基因是肉鸡腹水综合征的一个决定因素。
PLoS One. 2018 Jan 2;13(1):e0189544. doi: 10.1371/journal.pone.0189544. eCollection 2018.
5
Multi-generational genome wide association studies identify chromosomal regions associated with ascites phenotype.多代全基因组关联研究鉴定与腹水表型相关的染色体区域。
Poult Sci. 2017 Jun 1;96(6):1544-1552. doi: 10.3382/ps/pew478.
6
Quantitative trait loci with sex-specific effects for internal organs weights and hematocrit value in a broiler-layer cross.肉蛋鸡杂交群体中影响内脏器官重量和血细胞比容值的具有性别特异性效应的数量性状位点。
J Appl Genet. 2016 May;57(2):215-24. doi: 10.1007/s13353-015-0325-2. Epub 2015 Oct 24.
本文引用的文献
1
Pulmonary arterial hypertension (ascites syndrome) in broilers: a review.肉鸡肺动脉高压（腹水综合征）：综述。
Poult Sci. 2013 Jan;92(1):64-83. doi: 10.3382/ps.2012-02745.
2
Cardiovascular Disease, Single Nucleotide Polymorphisms; and the Renin Angiotensin System: Is There a MicroRNA Connection?心血管疾病、单核苷酸多态性与肾素血管紧张素系统：存在微小RNA联系吗？
Int J Hypertens. 2010 Aug 4;2010:281692. doi: 10.4061/2010/281692.
3
Differential expression of vasoactive mediators in microparticle-challenged lungs of chickens that differ in susceptibility to pulmonary arterial hypertension.在易感性不同的肺动脉高压鸡的微粒体挑战肺中，血管活性介质的差异表达。
Am J Physiol Regul Integr Comp Physiol. 2010 Jan;298(1):R235-42. doi: 10.1152/ajpregu.00451.2009. Epub 2009 Nov 11.
4
Differential gene expression of proinflammatory chemokines and cytokines in lungs of ascites-resistant and -susceptible broiler chickens following intravenous cellulose microparticle injection.静脉注射纤维素微粒后，抗腹水和易感腹水肉鸡肺中促炎趋化因子和细胞因子的差异基因表达
Vet Immunol Immunopathol. 2010 Feb 15;133(2-4):250-5. doi: 10.1016/j.vetimm.2009.07.011. Epub 2009 Jul 30.
5
Physiological parameters in broiler lines divergently selected for the incidence of ascites.针对腹水发病率进行不同选择的肉鸡品系中的生理参数。
Poult Sci. 2009 Sep;88(9):1984-90. doi: 10.3382/ps.2009-00116.
6
QTL for several metabolic traits map to loci controlling growth and body composition in an F2 intercross between high- and low-growth chicken lines.几个代谢性状的 QTL 位于控制高生长和低生长鸡系之间 F2 杂交后代生长和体组成的位点上。
Physiol Genomics. 2009 Aug 7;38(3):241-9. doi: 10.1152/physiolgenomics.90384.2008. Epub 2009 Jun 16.
7
Increased expression of urotensin II, urotensin II-related peptide and urotensin II receptor mRNAs in the cardiovascular organs of hypertensive rats: comparison with endothelin-1.高血压大鼠心血管器官中尾加压素II、尾加压素II相关肽及尾加压素II受体mRNA表达增加：与内皮素-1的比较
Peptides. 2009 Jun;30(6):1124-9. doi: 10.1016/j.peptides.2009.02.009. Epub 2009 Feb 21.
8
Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension.血管紧张素II 1型受体（AGTR1）的多态性与肺动脉高压诊断时的年龄相关。
J Heart Lung Transplant. 2009 Apr;28(4):373-9. doi: 10.1016/j.healun.2009.01.016.
9
Physiological, management and environmental triggers of the ascites syndrome: a review.腹水综合征的生理、管理和环境诱因：综述。
Avian Pathol. 2000 Dec;29(6):519-27. doi: 10.1080/03079450020016751.
10
Genome-wide assessment of worldwide chicken SNP genetic diversity indicates significant absence of rare alleles in commercial breeds.对全球鸡单核苷酸多态性（SNP）遗传多样性的全基因组评估表明，商业品种中显著缺乏稀有等位基因。
Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17312-7. doi: 10.1073/pnas.0806569105. Epub 2008 Nov 3.
Zotero 插件