Okonta J M, Uboh M, Obonga W O
Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Nigeria.
Indian J Pharm Sci. 2008 Mar-Apr;70(2):230-2. doi: 10.4103/0250-474X.41462.
The effect of ginger on the pharmacokinectic of metronidazole was studied using rabbits in a crossover study method. The relevance of this study borders on the wide use of ginger for culinary and phytotherapeutic purposes, and metronidazole that is commonly used for every gastrointestinal complain in our communities without prescription. Ginger significantly increased the absorption and plasma half-life, and significantly decreased the elimination rate constant and clearance of metronidazole (P<0.05). Thus, in clinical practice, the patients should be advised on the serious implication of using both items together.
采用交叉研究方法，在兔子身上研究了生姜对甲硝唑药代动力学的影响。这项研究的意义在于生姜在烹饪和植物治疗方面的广泛应用，以及在我们社区中无需处方就常用于各种胃肠道不适的甲硝唑。生姜显著提高了甲硝唑的吸收和血浆半衰期，并显著降低了其消除速率常数和清除率（P<0.05）。因此，在临床实践中，应告知患者同时使用这两种药物的严重后果。
