Vincenzo Cardinale, Rossella Semeraro, Alessia Torrice, Manuela Gatto, Cristina Napoli, Maria Consiglia Bragazzi, Raffaele Gentile, Domenico Alvaro, Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche, Sapienza University of Rome, 00185 Rome, Italy.
World J Gastrointest Oncol. 2010 Nov 15;2(11):407-16. doi: 10.4251/wjgo.v2.i11.407.
Cholangiocarcinoma (CCA) is a malignant tumour that arises from biliary epithelium at any portion of the biliary tree. CCA is currently classified as intra-hepatic or extra-hepatic CCA (EH-CCA). Recent evidences suggest that intra-hepatic CCA (IH-CCA) and EH-CCA are biologically different cancers, giving further support to a number of recent epidemiological studies showing large differences in terms of incidence, mortality and risk factors. The purpose of this manuscript is to review recent literature dealing with the descriptive epidemiology and risk factors of CCA with a special effort to compare IH- with EH-CCA.
胆管癌(CCA)是一种起源于胆道树任何部位的胆管上皮的恶性肿瘤。CCA 目前分为肝内或肝外 CCA(EH-CCA)。最近的证据表明,肝内胆管癌(IH-CCA)和 EH-CCA 是生物学上不同的癌症,这进一步支持了一些最近的流行病学研究,这些研究表明在发病率、死亡率和危险因素方面存在很大差异。本文的目的是回顾最近关于 CCA 的描述性流行病学和危险因素的文献,特别努力比较 IH-与 EH-CCA。