髓鞘相关糖蛋白的发育和病理生理学方面
Developmental and pathophysiological aspects of the myelin-associated glycoprotein.
作者信息
Brady R O, Quarles R H
机构信息
Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20892.
出版信息
Cell Mol Neurobiol. 1988 Jun;8(2):139-48. doi: 10.1007/BF00711240.
Abstract
- A glycoslylated sulfate-containing protein known as myelin-associated glycoprotein (MAG) appears to be unique to the central and peripheral nervous systems. This component has been characterized and cDNA clones have been isolated. 2. MAG is a member of the immunoglobulin superfamily. The principal form of MAG synthesized in brain during active myelination has an apparent molecular weight of 100,000. Alternate exon splicing leads to an additional 5000-dalton smaller form with a different C terminus. 3. In patients with multiple sclerosis, MAG is rapidly lost in areas of active disease. It is immunologically reactive in patients with benign monoclonal gammopathy associated with peripheral neuropathy. 4. The role of MAG in the formation of the myelin sheath and its participation in autoimmune neurological disorders are outlined.
摘要
- 一种名为髓鞘相关糖蛋白（MAG）的含硫酸化糖基化蛋白似乎是中枢神经系统和周围神经系统所特有的。该成分已得到表征，并且已分离出cDNA克隆。2. MAG是免疫球蛋白超家族的成员。在活跃髓鞘形成过程中大脑中合成的MAG的主要形式的表观分子量为100,000。可变外显子剪接导致形成一种额外的、C末端不同的小5000道尔顿的形式。3. 在多发性硬化症患者中，MAG在活跃病变区域迅速丢失。它在与周围神经病变相关的良性单克隆丙种球蛋白病患者中具有免疫反应性。4. 概述了MAG在髓鞘形成中的作用及其参与自身免疫性神经疾病的情况。
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本文引用的文献
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Identifying the protein products of brain-specific genes with antibodies to chemically synthesized peptides.使用针对化学合成肽段的抗体鉴定脑特异性基因的蛋白质产物。
Cell. 1983 Jul;33(3):671-82. doi: 10.1016/0092-8674(83)90010-7.
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Immunocytochemical studies of quaking mice support a role for the myelin-associated glycoprotein in forming and maintaining the periaxonal space and periaxonal cytoplasmic collar of myelinating Schwann cells.对颤抖小鼠的免疫细胞化学研究支持髓鞘相关糖蛋白在形成和维持髓鞘形成施万细胞的轴突周间隙和轴突周细胞质环中发挥作用。
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Elevated neutral protease activity in myelin from brains of patients with multiple sclerosis.多发性硬化症患者大脑髓鞘中中性蛋白酶活性升高。
Ann Neurol. 1984 Mar;15(3):264-7. doi: 10.1002/ana.410150310.
4
IgM in a human neuropathy related to paraproteinemia binds to a carbohydrate determinant in the myelin-associated glycoprotein and to a ganglioside.与副蛋白血症相关的人类神经病变中的IgM与髓鞘相关糖蛋白中的碳水化合物决定簇以及一种神经节苷脂结合。
Proc Natl Acad Sci U S A. 1984 Feb;81(4):1225-9. doi: 10.1073/pnas.81.4.1225.
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