简明弯曲杆菌与炎症性肠病
Campylobacter concisus and inflammatory bowel disease.
作者信息
Zhang Li, Lee Hoyul, Grimm Michael C, Riordan Stephen M, Day Andrew S, Lemberg Daniel A
机构信息
Li Zhang, Hoyul Lee, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
出版信息
World J Gastroenterol. 2014 Feb 7;20(5):1259-67. doi: 10.3748/wjg.v20.i5.1259.
Investigation of the possible role of Campylobacter concisus (C. concisus) in inflammatory bowel disease (IBD) is an emerging research area. Despite the association found between C. concisus and IBD, it has been difficult to explain how C. concisus, a bacterium that is commonly present in the human oral cavity, may contribute to the development of enteric diseases. The evidence presented in this review shows that some C. concisus strains in the oral cavity acquired zonula occludens toxin (zot) gene from a virus (prophage) and that C. concisus Zot shares conserved motifs with both Vibrio cholerae Zot receptor binding domain and human zonulin receptor binding domain. Both Vibrio cholerae Zot and human zonulin are known to increase intestinal permeability by affecting the tight junctions. Increased intestinal permeability is a feature of IBD. Based on these data, we propose that a primary barrier function defect caused by C. concisus Zot is a mechanism by which zot-positive C. concisus strains may trigger the onset and relapse of IBD.
对简明弯曲杆菌（C. concisus）在炎症性肠病（IBD）中可能作用的研究是一个新兴的研究领域。尽管已发现C. concisus与IBD之间存在关联，但一直难以解释一种常见于人口腔中的细菌C. concisus如何导致肠道疾病的发生。本综述中呈现的证据表明，口腔中的一些C. concisus菌株从一种病毒（前噬菌体）获得了小带闭合毒素（zot）基因，并且C. concisus Zot与霍乱弧菌Zot受体结合域和人zonulin受体结合域都有保守基序。已知霍乱弧菌Zot和人zonulin都会通过影响紧密连接来增加肠道通透性。肠道通透性增加是IBD的一个特征。基于这些数据，我们提出由C. concisus Zot引起的主要屏障功能缺陷是zot阳性C. concisus菌株可能引发IBD发作和复发的一种机制。
Zotero 插件