[人胃黏膜及胃癌中的胃蛋白酶原信使核糖核酸]
[Pepsinogen messenger RNA of human gastric mucosa and stomach cancer].
作者信息
Kalinovskiĭ V P, Glebov A V, Seĭts I F
出版信息
Eksp Onkol. 1988;10(3):36-7.
PMID:2457481
Abstract
The cell-free translation method has shown that pepsinogen mRNA is a predominant fraction in the total poly(A)+ RNA from human gastric mucosa. The pepsinogen protein with the molecular weight of 45 kDa has been identified. The level of pepsinogen mRNA decreased in tumours as compared with normal mucosa but in most cases pepsinogen mRNA synthesis depression was not total.
摘要
无细胞翻译方法表明，胃蛋白酶原mRNA是人类胃黏膜总poly(A)+ RNA中的主要部分。已鉴定出分子量为45 kDa的胃蛋白酶原蛋白。与正常黏膜相比，肿瘤中胃蛋白酶原mRNA的水平降低，但在大多数情况下，胃蛋白酶原mRNA合成的抑制并不完全。
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