[胃癌组织中胃蛋白酶原合成缺陷的亚细胞及分子机制]
[Subcellular and molecular mechanisms of a defect in pepsinogen synthesis in cancerous stomach tumors].
作者信息
Seĭts I F, Kalinovskiĭ V P
出版信息
Vopr Onkol. 1980;26(10):26-9.
The messenger RNA of pepsinogen from gastric tumors was found to show a lowered activity in providing the synthesis of a specific protein of gastric mucosa--pepsinogen in the acellular system. A relative amount of free polysomes in human gastric tumors is increased compared with the mucous membrane of the stomach. The pepsinogen messenger RNA of human gastric mucosa stimulates efficiently the in vitro incorporation of labelled leucin into the protein and induces the pepsinogen-pepsin synthesis in the polysome system of human gastric mucosa and rat liver.
在无细胞体系中发现，胃肿瘤中胃蛋白酶原的信使核糖核酸在提供胃黏膜特异性蛋白——胃蛋白酶原的合成方面活性降低。与胃黏膜相比，人类胃肿瘤中游离多核糖体的相对量增加。人类胃黏膜的胃蛋白酶原信使核糖核酸能有效刺激标记亮氨酸在体外掺入蛋白质，并在人类胃黏膜和大鼠肝脏的多核糖体体系中诱导胃蛋白酶原-胃蛋白酶的合成。
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