Hartnack Sonja
Section of Epidemiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Vet Anaesth Analg. 2014 May;41(3):227-32. doi: 10.1111/vaa.12143. Epub 2014 Feb 27.
Method comparison studies are needed for validation of new methods of measurements, for example, non-invasive blood pressure measurements against standard reference methods. After a brief introduction into method comparison studies, this paper is organized in three sections. The first section deals with the widely, though not always appropriately, used classical Bland-Altman plot with the limits of agreement and its extensions with non-constant bias and multiple observations. The second section comments on other statistical approaches including correlation coefficients, linear regressions and sensitivities and specificities which are sometimes seen in method comparison studies. The third section proposes the usage of linear mixed effects models as a flexible way to deal with questions associated with method comparison studies.
为验证新的测量方法，例如将无创血压测量与标准参考方法进行对比，需要进行方法比较研究。在简要介绍方法比较研究之后，本文分为三个部分。第一部分讨论广泛使用（尽管并非总是恰当使用）的具有一致性界限的经典布兰德-奥特曼图及其具有非恒定偏差和多个观测值的扩展。第二部分评论其他统计方法，包括相关系数、线性回归以及在方法比较研究中有时会见到的敏感性和特异性。第三部分提出使用线性混合效应模型作为处理与方法比较研究相关问题的灵活方式。
