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[Delayed wound healing during therapy of cutaneous graft-versus-host disease with everolimus].

作者信息

Brown A, Neumayer D, Rafieé-Tari Z, Krieg T, Eming S A

机构信息

Klinik und Poliklinik für Dermatologie und Venerologie, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

出版信息

Hautarzt. 2014 Jun;65(6):553-5. doi: 10.1007/s00105-014-2762-y.

DOI:10.1007/s00105-014-2762-y
PMID:24577262
Abstract

Graft-versus-host-disease (GvHD) is despite improvement in transplantation medicine the major cause for morbidity and mortality after allogeneic stem cell transplantation. We describe a patient with chronic cutaneous GvHD who developed massive skin ulcerations after changing the immunosuppressive therapy to a mammalian target of rapamycin (mTOR)-inhibitor.

摘要

相似文献

1
[Delayed wound healing during therapy of cutaneous graft-versus-host disease with everolimus].
Hautarzt. 2014 Jun;65(6):553-5. doi: 10.1007/s00105-014-2762-y.
2
Improvement of quality of life in patients with steroid-refractory chronic graft-versus-host disease treated with the mTOR inhibitor everolimus.使用mTOR抑制剂依维莫司治疗激素难治性慢性移植物抗宿主病患者的生活质量改善情况。
Clin Transplant. 2014 Dec;28(12):1410-5. doi: 10.1111/ctr.12472. Epub 2014 Nov 3.
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Therapy of sclerodermatous chronic graft-versus-host disease with mammalian target of rapamycin inhibitors.硬皮病样慢性移植物抗宿主病的哺乳动物雷帕霉素靶蛋白抑制剂治疗。
Biol Blood Marrow Transplant. 2011 May;17(5):657-63. doi: 10.1016/j.bbmt.2010.07.025. Epub 2010 Aug 7.
4
New perspectives on the use of mTOR inhibitors in allogeneic haematopoietic stem cell transplantation and graft-versus-host disease.mTOR抑制剂在异基因造血干细胞移植和移植物抗宿主病中的应用新视角。
Br J Clin Pharmacol. 2016 Nov;82(5):1171-1179. doi: 10.1111/bcp.13022. Epub 2016 Jun 22.
5
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J Clin Oncol. 2008 Dec 10;26(35):5767-74. doi: 10.1200/JCO.2008.17.7279. Epub 2008 Nov 10.
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Curr Opin Hematol. 2010 Nov;17(6):500-4. doi: 10.1097/MOH.0b013e32833e5b2e.
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Mammalian target of rapamycin inhibitor-associated stomatitis in hematopoietic stem cell transplantation patients receiving sirolimus prophylaxis for graft-versus-host disease.接受西罗莫司预防移植物抗宿主病的造血干细胞移植患者中雷帕霉素哺乳动物靶点抑制剂相关口腔炎
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Psoralen plus ultraviolet-A-bath photochemotherapy as an adjunct treatment modality in cutaneous chronic graft versus host disease.补骨脂素加紫外线A浴光化学疗法作为皮肤慢性移植物抗宿主病的辅助治疗方式
Photodermatol Photoimmunol Photomed. 2002 Aug;18(4):183-90. doi: 10.1034/j.1600-0781.2002.00719.x.
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Severe cutaneous ulceration following treatment with thalidomide for GVHD.
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Coordinating energy metabolism and signaling pathways in epithelial self-renewal and differentiation.在上皮细胞自我更新和分化过程中协调能量代谢与信号通路。
Biol Direct. 2024 Aug 7;19(1):63. doi: 10.1186/s13062-024-00510-0.
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The regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling.

本文引用的文献

1
Sirolimus and secondary skin-cancer prevention in kidney transplantation.西罗莫司与肾移植术后皮肤癌二级预防。
N Engl J Med. 2012 Jul 26;367(4):329-39. doi: 10.1056/NEJMoa1204166.
2
Defining the role of sirolimus in the management of graft-versus-host disease: from prophylaxis to treatment.明确西罗莫司在移植物抗宿主病管理中的作用：从预防到治疗。
Biol Blood Marrow Transplant. 2013 Jan;19(1):12-21. doi: 10.1016/j.bbmt.2012.06.020. Epub 2012 Jul 5.
3
Effects of immunosuppressive therapy on wound healing.免疫抑制疗法对伤口愈合的影响。
通过表皮mTOR信号的时空激活对皮肤稳态、修复及皮肤疾病发病机制的调节
Front Cell Dev Biol. 2022 Jul 22;10:950973. doi: 10.3389/fcell.2022.950973. eCollection 2022.
4
New perspectives on the use of mTOR inhibitors in allogeneic haematopoietic stem cell transplantation and graft-versus-host disease.mTOR抑制剂在异基因造血干细胞移植和移植物抗宿主病中的应用新视角。
Br J Clin Pharmacol. 2016 Nov;82(5):1171-1179. doi: 10.1111/bcp.13022. Epub 2016 Jun 22.
Int Wound J. 2013 Feb;10(1):98-104. doi: 10.1111/j.1742-481X.2012.00950.x. Epub 2012 Feb 24.
4
Mammalian target of rapamycin (mTOR) inhibitors slow skin carcinogenesis, but impair wound healing.哺乳动物雷帕霉素靶蛋白（mTOR）抑制剂可减缓皮肤癌变，但会损害伤口愈合。
Br J Dermatol. 2012 Feb;166(2):422-4. doi: 10.1111/j.1365-2133.2011.10591.x. Epub 2011 Dec 5.
5
Rapamycin-induced impaired wound healing is associated with compromised tissue lactate accumulation and extracellular matrix remodeling.雷帕霉素诱导的伤口愈合受损与组织乳酸积累受损和细胞外基质重塑有关。
Eur Surg Res. 2011;47(1):39-44. doi: 10.1159/000327972. Epub 2011 May 20.
6
[Graft-versus-host disease (GvHD) - an update. Part 2: prognosis and therapy of GvHD].[移植物抗宿主病（GvHD）——最新进展。第2部分：GvHD的预后与治疗]
Hautarzt. 2011 Mar;62(3):229-37; quiz 238-9. doi: 10.1007/s00105-010-2118-1.
7
[Graft-versus-Host Disease (GvHD) - an update : Part 1: Pathophysiology, clinical features and classification of GvHD].[移植物抗宿主病（GvHD）——最新进展：第1部分：GvHD的病理生理学、临床特征及分类]
Hautarzt. 2011 Feb;62(2):139-54; quiz 155. doi: 10.1007/s00105-010-2107-4.
8
Therapy of sclerodermatous chronic graft-versus-host disease with mammalian target of rapamycin inhibitors.硬皮病样慢性移植物抗宿主病的哺乳动物雷帕霉素靶蛋白抑制剂治疗。
Biol Blood Marrow Transplant. 2011 May;17(5):657-63. doi: 10.1016/j.bbmt.2010.07.025. Epub 2010 Aug 7.
9
Consensus conference on clinical practice in chronic graft-versus-host disease (GVHD): first-line and topical treatment of chronic GVHD.慢性移植物抗宿主病（GVHD）临床实践共识会议：慢性 GVHD 的一线和局部治疗。
Biol Blood Marrow Transplant. 2010 Dec;16(12):1611-28. doi: 10.1016/j.bbmt.2010.06.015. Epub 2010 Jun 25.
10
Accelerated wound healing by mTOR activation in genetically defined mouse models.通过 mTOR 激活在遗传定义的小鼠模型中加速伤口愈合。
PLoS One. 2010 May 13;5(5):e10643. doi: 10.1371/journal.pone.0010643.