Wan Zhihui, Mao Huajian, Guo Miao, Li Yanli, Zhu Aijun, Yang Hong, He Hui, Shen Junkang, Zhou Lijuan, Jiang Zhen, Ge Cuicui, Chen Xiaoyuan, Yang Xiangliang, Liu Gang, Chen Huabing
1. Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, and College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
2. Radiology Department, Second Affiliated Hospital, Soochow University, Suzhou 215004, China.
Theranostics. 2014 Jan 29;4(4):399-411. doi: 10.7150/thno.8171. eCollection 2014.
It is highly desirable to develop theranostic nanoparticles for achieving cancer imaging with enhanced contrast and simultaneously multimodal synergistic therapy. Herein, we report a theranostic micelle system hierarchically assembling cyanine dye (indocyanine green) and chemotherapeutic compound (doxorubicin) (I/D-Micelles) as a novel theranostic platform with high drug loading, good stability and enhanced cellular uptake via clathrin-mediated endocytosis. I/D-Micelles exhibit the multiple functionalities including near-infrared fluorescence (NIRF), hyperthermia and intracellular singlet oxygen from indocyanine green, and simultaneous cytotoxicity from doxorubicin. Upon photoirradiation, I/D-Micelles can induce NIRF imaging, acute photothermal therapy via hyperthermia and simultaneous synergistic chemotherapy via singlet oxygen-triggered disruption of lysosomal membranes, eventually leading to enhanced NIRF imaging and superior tumor eradication without any re-growth. Our results suggest that the hierarchical micelles can act as a superior theranostic platform for cancer imaging and multimodal synergistic therapy.
开发用于实现具有增强对比度的癌症成像并同时进行多模态协同治疗的诊疗纳米颗粒是非常可取的。在此，我们报告了一种诊疗胶束系统，其通过分层组装花菁染料（吲哚菁绿）和化疗化合物（阿霉素）（I/D-胶束）作为一种新型的诊疗平台，具有高药物负载量、良好的稳定性以及通过网格蛋白介导的内吞作用增强细胞摄取。I/D-胶束具有多种功能，包括来自吲哚菁绿的近红外荧光（NIRF）、热疗和细胞内单线态氧，以及来自阿霉素的同步细胞毒性。在光照射下，I/D-胶束可诱导NIRF成像、通过热疗进行急性光热治疗以及通过单线态氧引发的溶酶体膜破坏进行同步协同化疗，最终导致增强的NIRF成像和优异的肿瘤根除效果且无任何复发。我们的结果表明，分层胶束可作为用于癌症成像和多模态协同治疗的优异诊疗平台。
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