Ningxia Medical University, Postgraduate Training Base in Shanghai Gongli Hospital, Pudong New Area, No. 219 Miao Pu Road, Shanghai 200135, China.
Department of Gastroenterology, Changhai Hospital, Naval Medical University, No. 168 Changhai Road, Shanghai 200433, China.
Molecules. 2022 Oct 25;27(21):7238. doi: 10.3390/molecules27217238.
Acute pancreatitis (AP) is a complex inflammatory disease caused by multiple etiologies, the pathogenesis of which has not been fully elucidated. Oxidative stress is important for the regulation of inflammation-related signaling pathways, the recruitment of inflammatory cells, the release of inflammatory factors, and other processes, and plays a key role in the occurrence and development of AP. In recent years, antioxidant therapy that suppresses oxidative stress by scavenging reactive oxygen species has become a research highlight of AP. However, traditional antioxidant drugs have problems such as poor drug stability and low delivery efficiency, which limit their clinical translation and applications. Nanomaterials bring a brand-new opportunity for the antioxidant treatment of AP. This review focuses on the multiple advantages of nanomaterials, including small size, good stability, high permeability, and long retention effect, which can be used not only as effective carriers of traditional antioxidant drugs but also directly as antioxidants. In this review, after first discussing the association between oxidative stress and AP, we focused on summarizing the literature related to antioxidant nanomaterials for the treatment of AP and highlighting the effects of these nanomaterials on the indicators related to oxidative stress in pathological states, aiming to provide references for follow-up research and promote clinical application.
急性胰腺炎（AP）是一种由多种病因引起的复杂炎症性疾病，其发病机制尚未完全阐明。氧化应激在炎症相关信号通路的调节、炎症细胞的募集、炎症因子的释放等过程中起着重要作用，在 AP 的发生和发展中起着关键作用。近年来，通过清除活性氧来抑制氧化应激的抗氧化治疗已成为 AP 的研究热点。然而，传统的抗氧化药物存在药物稳定性差、递送效率低等问题，限制了其在临床的转化和应用。纳米材料为 AP 的抗氧化治疗带来了全新的机会。本综述重点介绍了纳米材料的多个优势，包括尺寸小、稳定性好、通透性高和滞留时间长，不仅可以作为传统抗氧化药物的有效载体，还可以直接作为抗氧化剂。在本综述中，我们首先讨论了氧化应激与 AP 的关联，然后重点总结了用于治疗 AP 的抗氧化纳米材料的相关文献，并强调了这些纳米材料对病理状态下与氧化应激相关指标的影响，旨在为后续研究提供参考，并促进其临床应用。
