a Laboratory of Pharmaceutical Microbiology , Ghent University , Ghent , Belgium.
Biofouling. 2014;30(3):377-83. doi: 10.1080/08927014.2013.878333. Epub 2014 Feb 28.
Microbial biofilms are a serious threat to human health. Recent studies have indicated that many clinically relevant biofilms are polymicrobial. In the present study, multispecies biofilms were grown in a reproducible manner in a 96-well microtiter plate. The efficacy of nine commercially available disinfectants against Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa in multispecies biofilms was determined and compared. The results showed that the direction and the magnitude of the effect in a multispecies biofilm depend on the strain and the disinfectant used and challenge the common belief that organisms in multispecies biofilms are always less susceptible than in monospecies biofilms.
微生物生物膜对人类健康构成严重威胁。最近的研究表明，许多临床上相关的生物膜是多菌种的。在本研究中，以可重复的方式在 96 孔微量滴定板中培养了多菌种生物膜。测定并比较了 9 种市售消毒剂对金黄色葡萄球菌、白色念珠菌和铜绿假单胞菌在多菌种生物膜中的功效。结果表明，多菌种生物膜中的效果的方向和程度取决于所用菌株和消毒剂，这与多菌种生物膜中的生物体通常比单菌种生物膜中的生物体更不易受影响的普遍观点相矛盾。
