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用于牙槽嵴拔牙窝保存的带瓣术与无瓣术:一项随机临床试验的组织学评估

Flap versus flapless procedure for ridge preservation in alveolar extraction sockets: a histological evaluation in a randomized clinical trial.

作者信息

Barone Antonio, Borgia Valentina, Covani Ugo, Ricci Massimiliano, Piattelli Adriano, Iezzi Giovanna

机构信息

Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy.

AOU of Pisa, Pisa, Italy.

出版信息

Clin Oral Implants Res. 2015 Jul;26(7):806-13. doi: 10.1111/clr.12358. Epub 2014 Mar 1.

Abstract

OBJECTIVE

The aim of this study was to evaluate and compare the histological and histomorphometric features of two different procedures carried out in extraction socket grafting; namely, the flapped and flapless technique.

MATERIALS AND METHODS

Patients considered eligible for the study were randomized to receive tooth extraction and ridge preservation with the porcine bone and collagen membrane, with a full thickness mucoperiosteal flap and primary soft tissue closure (control group), or, with a flapless procedure and a secondary soft tissue closure (test group). After 3 months of healing, the surgical re-entry procedure was performed and implants were inserted in the test as well as in the control sites. Bone core samples were harvested from both groups and processed to be observed under light microscopy. Outcome variables were percentages of newly formed bone, residual graft particles and marrow spaces.

RESULTS

Thirty-four patients were enrolled in the study. All of the scheduled implants were placed. Histological and histomorphometrical analyses did not report significant differences between the two groups (with P-values ranging from 0.690 to 0.917). The mean percentages of newly formed bone, soft tissues and residual grafted particles were 22.5 and 22.5%, 59.3 and 59.4%, and 18.6 and 18.2% respectively for flap and flapless approach.

CONCLUSION

No histological and histomorphometrical differences were observed when comparing the flap and the flapless technique for tooth extraction and socket grafting procedures.

摘要

目的

本研究旨在评估和比较拔牙窝植骨术中两种不同操作方法(即翻瓣技术和不翻瓣技术)的组织学和组织形态计量学特征。

材料与方法

符合研究条件的患者被随机分为两组,一组接受拔牙并使用猪骨和胶原膜进行牙槽嵴保存,采用全厚粘骨膜瓣并一期关闭软组织(对照组);另一组采用不翻瓣操作和二期关闭软组织(试验组)。愈合3个月后,进行再次手术入路操作,并在试验组和对照组部位植入种植体。从两组采集骨芯样本,进行处理后在光学显微镜下观察。观察指标为新形成骨、残留移植颗粒和骨髓腔的百分比。

结果

34例患者纳入本研究。所有计划植入的种植体均已植入。组织学和组织形态计量学分析显示两组之间无显著差异(P值范围为0.690至0.917)。翻瓣和不翻瓣方法新形成骨、软组织和残留移植颗粒的平均百分比分别为22.5%和22.5%、59.3%和59.4%、18.6%和18.2%。

结论

在比较翻瓣和不翻瓣技术用于拔牙和牙槽窝植骨手术时,未观察到组织学和组织形态计量学差异。

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