Hashimoto T, Tori M, Asakawa Y, Wollenweber E
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Z Naturforsch C J Biosci. 1988 May-Jun;43(5-6):470-2. doi: 10.1515/znc-1988-5-625.
The prenyl ester and the phenylethyl ester of caffeic acid, formed in the bud excretion of poplar species, were shown recently to be the major contact allergens in bee-glue. An unambiguous synthesis of these compounds, based on the reaction of caffeic acid with 1-bromo-3-methyl-2-butene and with beta-bromoethylbenzene, respectively, is reported. The synthetic products confirm the previously described structures of the natural products and allow further testing of their allergenic properties.
最近研究表明，杨树芽排泄物中形成的咖啡酸异戊烯酯和苯乙酯是蜂胶中的主要接触性过敏原。本文报道了分别基于咖啡酸与1-溴-3-甲基-2-丁烯以及β-溴乙苯的反应对这些化合物进行的明确合成。合成产物证实了先前描述的天然产物结构，并允许对其致敏特性进行进一步测试。
