rs4779584基因多态性与结直肠癌风险的Meta分析。
Meta-analysis of the rs4779584 polymorphism and colorectal cancer risk.
作者信息
Yang Hua, Gao Ya, Feng Tian, Jin Tian-Bo, Kang Long-Li, Chen Chao
机构信息
School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
School of Medicine, Xi'an Jiaotong University, Xi'an, China.
出版信息
PLoS One. 2014 Feb 24;9(2):e89736. doi: 10.1371/journal.pone.0089736. eCollection 2014.
PURPOSE
Several researchers have suggested that the rs4779584 (15q13.3) polymorphism is associated with an increased risk of developing colorectal cancer (CRC). However, past results remain inconclusive. We addressed this controversy by performing a meta-analysis of the relationship between rs4779584 of GREM1-SCG5 and colorectal cancer.
METHODS
We selected 12 case-control studies involving 11,769 cases of CRC and 14,328 healthy controls. The association between the rs4779584 polymorphism and CRC was examined by the overall odds ratio (OR) with a 95% confidence interval (CI). We used different genetic model analyses, sensitivity analyses, and assessments of bias in our meta-analysis.
RESULTS
GREM1-SCG5 rs4779584 polymorphisms were associated with CRC in all of the genetic models that were examined in this meta-analysis of 12 case-control studies.
CONCLUSION
GREM1-SCG5 rs4779584 polymorphisms may increase the risk of developing colorectal cancer.
目的
几位研究人员提出，rs4779584（15q13.3）多态性与患结直肠癌（CRC）风险增加相关。然而，过去的结果仍无定论。我们通过对GREM1 - SCG5的rs4779584与结直肠癌之间的关系进行荟萃分析来解决这一争议。
方法
我们选取了12项病例对照研究，涉及11769例CRC病例和14328例健康对照。通过总体比值比（OR）及95%置信区间（CI）检验rs4779584多态性与CRC之间的关联。我们在荟萃分析中采用了不同的遗传模型分析、敏感性分析及偏倚评估。
结果
在这项对12项病例对照研究的荟萃分析中，所检测的所有遗传模型中，GREM1 - SCG5 rs4779584多态性均与CRC相关。
结论
GREM1 - SCG5 rs4779584多态性可能会增加患结直肠癌的风险。
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