Zosky Graeme R, Iosifidis Thomas, Perks Kara, Ditcham Will G F, Devadason Sunalene G, Siah W Shan, Devine Brian, Maley Fiona, Cook Angus
School of Medicine, University of Tasmania, Hobart, Tasmania, Australia ; Cooperative Research Centre for Asthma and Airways, Sydney, New South Wales, Australia.
Telethon Institute for Child Health Research, Subiaco, Western Australia, Australia.
PLoS One. 2014 Feb 28;9(2):e90609. doi: 10.1371/journal.pone.0090609. eCollection 2014.
There are many communities around the world that are exposed to high levels of particulate matter <10 µm (PM₁₀) of geogenic (earth derived) origin. Mineral dusts in the occupational setting are associated with poor lung health, however very little is known about the impact of heterogeneous community derived particles. We have preliminary evidence to suggest that the concentration of iron (Fe) may be associated with the lung inflammatory response to geogenic PM₁₀. We aimed to determine which physico-chemical characteristics of community sampled geogenic PM₁₀ are associated with adverse lung responses.
We collected geogenic PM₁₀ from four towns in the arid regions of Western Australia. Adult female BALB/c mice were exposed to 100 µg of particles and assessed for inflammatory and lung function responses 6 hours, 24 hours and 7 days post-exposure. We assessed the physico-chemical characteristics of the particles and correlated these with lung outcomes in the mice using principal components analysis and multivariate linear regression.
Geogenic particles induced an acute inflammatory response that peaked 6 hours post-exposure and a deficit in lung mechanics 7 days post-exposure. This deficit in lung mechanics was positively associated with the concentration of Fe and particle size variability and inversely associated with the concentration of Si.
The lung response to geogenic PM₁₀ is complex and highly dependent on the physico-chemical characteristics of the particles. In particular, the concentration of Fe in the particles may be a key indicator of the potential population health consequences for inhaling geogenic PM₁₀.
世界各地有许多社区暴露于高浓度的源自地质（地球衍生）的小于10微米颗粒物（PM₁₀）中。职业环境中的矿物粉尘与肺部健康不佳有关，然而对于源自社区的异质颗粒物的影响却知之甚少。我们有初步证据表明，铁（Fe）的浓度可能与对地质源PM₁₀的肺部炎症反应有关。我们旨在确定从社区采集的地质源PM₁₀的哪些物理化学特征与不良肺部反应相关。
我们从西澳大利亚干旱地区的四个城镇收集了地质源PM₁₀。成年雌性BALB/c小鼠暴露于100微克颗粒物，并在暴露后6小时、24小时和7天评估其炎症和肺功能反应。我们评估了颗粒物的物理化学特征，并使用主成分分析和多元线性回归将这些特征与小鼠的肺部结果进行关联。
地质源颗粒物引发了急性炎症反应，在暴露后6小时达到峰值，并在暴露后7天出现肺力学功能缺陷。这种肺力学功能缺陷与铁的浓度和颗粒大小变异性呈正相关，与硅的浓度呈负相关。
肺部对地质源PM₁₀的反应是复杂的，并且高度依赖于颗粒物的物理化学特征。特别是，颗粒物中铁的浓度可能是吸入地质源PM₁₀对人群健康潜在影响的关键指标。
