空气氧化芳樟醇在过敏患者中引发湿疹的重复开放性应用测试研究。
Air-oxidized linalool elicits eczema in allergic patients - a repeated open application test study.
机构信息
Department of Dermatology, Sahlgrenska Academy at University of Gothenburg, 41345 Gothenburg, Sweden.
出版信息
Contact Dermatitis. 2014 Mar;70(3):129-38. doi: 10.1111/cod.12163.
BACKGROUND
Linalool is a commonly used fragrance terpene that forms potent sensitizers upon oxidation. In a recent multicentre study, we found that 7% of 2900 patients showed positive patch test reactions to oxidized linalool at 6.0%. No elicitation studies have been performed.
OBJECTIVE
To identify threshold concentrations for elicitation of allergic contact dermatitis caused by oxidized linalool in allergic individuals with repeated exposures.
METHODS
Repeated open application tests were performed in 6 participants previously diagnosed with contact allergy to oxidized linalool. Creams containing 3.0%, 1.0% and 0.30% oxidized linalool (corresponding to 0.56%, 0.19% and 0.056% linalool hydroperoxides, respectively) and 'fine fragrance' containing 1.0%, 0.30% and 0.10% oxidized linalool (corresponding to 0.19%, 0.056% and 0.019% linalool hydroperoxides, respectively) were used twice daily for up to 3 weeks. Patch testing with a dilution series of oxidized linalool was performed.
RESULTS
Five of 6 participants reacted to the cream containing 3% oxidized linalool. With 1% oxidized linalool, a reaction was seen in 3 (cream) and 4 (fine fragrance) participants, respectively. With 0.3% oxidized linalool, 2 (cream) and 1 (fine fragrance) participants reacted.
CONCLUSION
Repeated exposure to low concentrations of oxidized linalool can elicit allergic contact dermatitis in previously sensitized individuals.
背景
芳樟醇是一种常用的香料萜烯，氧化后会形成强致敏剂。在最近的一项多中心研究中，我们发现 2900 名患者中有 7%对 6.0%氧化芳樟醇的斑贴试验呈阳性反应。尚未进行激发研究。
目的
确定在反复接触氧化芳樟醇的过敏个体中，氧化芳樟醇引起变应性接触性皮炎的激发阈值浓度。
方法
对 6 名先前诊断为氧化芳樟醇接触过敏的参与者进行重复开放应用测试。含有 3.0%、1.0%和 0.30%氧化芳樟醇（分别对应 0.56%、0.19%和 0.056%芳樟醇氢过氧化物）的乳膏和含有 1.0%、0.30%和 0.10%氧化芳樟醇（分别对应 0.19%、0.056%和 0.019%芳樟醇氢过氧化物）的“香精”乳膏，每天使用两次，持续 3 周。进行氧化芳樟醇稀释系列斑贴试验。
结果
6 名参与者中有 5 名对含 3%氧化芳樟醇的乳膏产生反应。使用 1%氧化芳樟醇时，分别有 3 名（乳膏）和 4 名（香精）参与者产生反应。使用 0.3%氧化芳樟醇时，有 2 名（乳膏）和 1 名（香精）参与者产生反应。
结论
在先前致敏的个体中，重复接触低浓度的氧化芳樟醇可引起变应性接触性皮炎。
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