Department of Dermatology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Contact Dermatitis. 2012 Nov;67(5):247-59. doi: 10.1111/j.1600-0536.2012.02134.x. Epub 2012 Aug 21.
Linalool is a common fragrance terpene that, in pure form, is not allergenic or is a very weak allergen. However, linalool autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a Swedish study, oxidized linalool 6.0% in petrolatum (pet.) gave 5% positive patch test reactions in 2500 dermatitis patients.
To investigate whether oxidized linalool 6%, with a stable concentration of the main haptens, the linalool hydroperoxides (Lin-OOHs) in pet., could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized linalool 6.0% (Lin-OOHs 1%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia.
Overall, 6.9% (range 3-13%) of the patients showed positive patch test reactions to oxidized linalool. Doubtful reactions were found in 9.2% of the patients (range 0-36%). Few irritant reactions were seen.
In an international setting, oxidized linalool has been shown to be a common allergen. Oxidized linalool 6.0% (Lin-OOHs 1%) pet. is a useful, standardized and stable tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized linalool would not have been informed of their fragrance allergy if this specific test had not been performed.
芳樟醇是一种常见的香料萜烯，纯品无致敏性或致敏性非常弱。然而，芳樟醇在暴露于空气中时会自动氧化，其氧化产物可引起接触过敏。在瑞典的一项研究中，含有 6.0%氧化芳樟醇的凡士林（pet.）引起 2500 例皮炎患者中有 5%出现阳性斑贴试验反应。
研究含有稳定浓度主要半抗原、芳樟醇氢过氧化物（Lin-OOHs）的 6%氧化芳樟醇（pet.）是否可作为一种有用的工具，用于检测国际范围内的接触过敏。方法。在丹麦、英国、新加坡、西班牙、瑞典和澳大利亚的 2900 例连续皮炎患者中测试了 6.0%氧化芳樟醇（Lin-OOHs 1%）pet.。
总的来说，6.9%（范围 3-13%）的患者对氧化芳樟醇出现阳性斑贴试验反应。在 9.2%（范围 0-36%）的患者中发现可疑反应。很少出现刺激性反应。
在国际范围内，氧化芳樟醇已被证实为常见过敏原。6.0%氧化芳樟醇（Lin-OOHs 1%）pet.是一种有用的、标准化的、稳定的工具，可用于检测皮炎患者的接触过敏。如果没有进行这种特异性测试，许多对氧化芳樟醇出现阳性斑贴试验反应的患者将不会被告知他们的香料过敏。
