Department of Dermatology, Sahlgrenska Academy, University of Gothenburg, 412 96 Gothenburg, Sweden.
Contact Dermatitis. 2012 Jul;67(1):20-7. doi: 10.1111/j.1600-0536.2012.02079.x.
The fragrance terpene geraniol forms sensitizing compounds via autoxidation and skin metabolism. Geranial and neral, the two isomers of citral, are the major haptens formed in both of these activation pathways.
To investigate whether testing with oxidized geraniol detects more cases of contact allergy than testing with pure geraniol.
The pattern of reactions to pure and oxidized geraniol, and metabolites/autoxidation products, was studied to investigate the importance of autoxidation or cutaneous metabolism in contact allergy to geraniol. Pure and oxidized geraniol were tested at 2.0% petrolatum in 2227 and 2179 consecutive patients, respectively. In parallel, geranial, neral and citral were tested in 2152, 1626 and 1055 consecutive patients, respectively.
Pure and oxidized geraniol gave positive patch test reactions in 0.13% and 0.55% of the patients, respectively. Eight of 11 patients with positive patch test reactions to oxidized geraniol also reacted to citral or its components. Relevance for the positive patch test reactions in relation to the patients' dermatitis was found in 11 of 14 cases.
Testing with oxidized geraniol could detect more cases of contact allergy to geraniol. The reaction pattern of the 14 cases presented indicates that both autoxidation and metabolism could be important in sensitization to geraniol.
香茅醇作为一种萜类化合物，可通过自动氧化和皮肤代谢形成致敏化合物。柠檬醛的两种同分异构体香叶醛和橙花醛是这两种激活途径中形成的主要半抗原。
研究用氧化香茅醇检测是否比用纯香茅醇检测接触过敏的病例更多。
研究了对纯香茅醇和氧化香茅醇以及代谢物/自动氧化产物的反应模式，以研究自动氧化或皮肤代谢在香茅醇接触过敏中的重要性。在 2227 例和 2179 例连续患者中，分别用 2.0%凡士林测试纯香茅醇和氧化香茅醇。同时，在 2152 例、1626 例和 1055 例连续患者中分别测试了香叶醛、橙花醛和柠檬醛。
纯香茅醇和氧化香茅醇分别在 0.13%和 0.55%的患者中引起阳性斑贴试验反应。11 例对氧化香茅醇呈阳性斑贴试验反应的患者中，有 8 例也对柠檬醛或其成分有反应。在 14 例病例中，有 11 例与患者皮炎相关的阳性斑贴试验反应具有相关性。
用氧化香茅醇检测可检测到更多的香茅醇接触过敏病例。14 例病例的反应模式表明，自动氧化和代谢都可能是香茅醇致敏的重要因素。
