Department of Dermatology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Contact Dermatitis. 2010 Jan;62(1):32-41. doi: 10.1111/j.1600-0536.2009.01657.x.
Linalool is a widely used fragrance terpene. Pure linalool is not allergenic or a very weak allergen, but autoxidizes on air exposure and the oxidation products can cause contact allergy. Oxidized (ox.) linalool has previously been patch tested at a concentration of 2.0% in petrolatum (pet.) in 1511 patients, and 1.3% positive patch test reactions were observed.
To investigate the optimal patch test concentration for detection of contact allergy to ox. linalool.
Four concentrations of ox. linalool (2.0%, 4.0%, 6.0%, 11.0% pet.) were tested in 3418 consecutive dermatitis patients.
Ox. linalool 2.0%, 4.0%, 6.0%, and 11.0% pet. detected positive patch test reactions in 0.83%, 3.2%, 5.3%, and 7.2% of the tested patients, respectively. The doubtful reactions increased with rising concentrations but relatively less, giving 5.1%, 6.4%, and 7.3% doubtful reactions, respectively, for ox. linalool 4.0%, 6.0%, and 11.0% pet. Few irritative reactions were seen.
Raising the patch test concentration for ox. linalool gave a better detection of contact allergy, as many as 5-7% positive patch test reactions were detected. We suggest a patch test concentration of ox. linalool 6.0% pet. for future patch testing, giving a dose per unit area of 2.4 mg/cm(2) when 20 mg test substance is tested in small Finn Chambers.
芳樟醇是一种广泛使用的香气萜烯。纯芳樟醇不是过敏原或弱过敏原，但在暴露于空气中时会自动氧化，其氧化产物会引起接触过敏。先前已在 1511 例患者中用 2.0%（w/w）芳樟醇在凡士林（pet.）中进行斑贴试验，观察到 1.3%阳性斑贴试验反应。
研究检测氧化芳樟醇（ox. linalool）接触过敏的最佳斑贴试验浓度。
对 3418 例连续的皮炎患者进行了 4 种浓度的 ox. linalool（2.0%、4.0%、6.0%、11.0% pet.）斑贴试验。
ox. linalool 2.0%、4.0%、6.0%和 11.0% pet.在分别检测的患者中，阳性斑贴试验反应发生率为 0.83%、3.2%、5.3%和 7.2%。可疑反应随着浓度的升高而增加，但相对较少，ox. linalool 4.0%、6.0%和 11.0% pet.的可疑反应发生率分别为 5.1%、6.4%和 7.3%。未见明显刺激性反应。
升高 ox. linalool 的斑贴试验浓度可更好地检测接触过敏，阳性斑贴试验反应率可达 5%-7%。我们建议未来的斑贴试验使用 6.0%（w/w）ox. linalool 浓度的 pet.制剂，当在小 Finn 室中测试 20mg 受试物时，单位面积的剂量为 2.4mg/cm(2)。
