老年人的急性期反应物。

Acute phase reactants in the elderly.

作者信息

Milman N, Graudal N, Andersen H C

机构信息

Department of Medicine P, Bispebjerg Hospital, Copenhagen, Denmark.

出版信息

Clin Chim Acta. 1988 Aug 15;176(1):59-62. doi: 10.1016/0009-8981(88)90174-x.

DOI:10.1016/0009-8981(88)90174-x

PMID:2458869

Abstract

The erythrocyte sedimentation rate (ESR), plasma fibrinogen, serum orosomucoid, serum alpha 1-antitrypsin and serum haptoglobin were measured in 267 apparently healthy elderly subjects (median age 79 years, range 60-93), and compared to the values in 58 healthy younger subjects (median age 27 years, range 18-50). The acute phase reactants displayed no sex differences, but were significantly higher in elderly than in younger persons (mean +/- SD): ESR 13 +/- 10 mm/h vs 4 +/- 3 mm/h (p less than 0.001); fibrinogen 4.35 +/- 0.95 g/l vs 3.33 +/- 0.54 g/l (p less than 0.001); orosomucoid 0.68 +/- 0.20 g/l vs 0.60 +/- 0.16 g/l (p less than 0.01); alpha 1-antitrypsin 2.16 +/- 0.38 g/l vs 1.84 +/- 0.43 g/l (p less than 0.001); haptoglobin 1.30 +/- 0.50 g/l vs 1.00 +/- 0.30 g/l (p less than 0.001). Correlations existed between the acute phase reactants, being highest between ESR and fibrinogen (r = 0.53, p less than 0.001).

摘要

对267名看似健康的老年人（年龄中位数79岁，范围60 - 93岁）测量了红细胞沉降率（ESR）、血浆纤维蛋白原、血清类粘蛋白、血清α1 - 抗胰蛋白酶和血清触珠蛋白，并与58名健康年轻人（年龄中位数27岁，范围18 - 50岁）的值进行比较。急性期反应物无性别差异，但老年人的水平显著高于年轻人（均值±标准差）：ESR为13±10mm/h，而年轻人为4±3mm/h（p<0.001）；纤维蛋白原为4.35±0.95g/L，而年轻人为3.33±0.54g/L（p<0.001）；类粘蛋白为0.68±0.20g/L，而年轻人为0.60±0.16g/L（p<0.01）；α1 - 抗胰蛋白酶为2.16±0.38g/L，而年轻人为1.84±0.43g/L（p<0.001）；触珠蛋白为1.30±0.50g/L，而年轻人为1.00±0.30g/L（p<0.001）。急性期反应物之间存在相关性，ESR与纤维蛋白原之间的相关性最高（r = 0.53，p<0.001）。