Boffetta Paolo, Fordyce Tiffani, Mandel Jack S
aTisch Cancer Institute and Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, New York bExponent Inc., Menlo Park, California, USA.
Eur J Cancer Prev. 2014 Nov;23(6):587-93. doi: 10.1097/CEJ.0000000000000013.
This study investigated lung cancer and other diseases related to insoluble beryllium compounds. A cohort of 4950 workers from four US insoluble beryllium manufacturing facilities were followed through 2009. Expected deaths were calculated using local and national rates. On the basis of local rates, all-cause mortality was significantly reduced. Mortality from lung cancer (standardized mortality ratio 96.0; 95% confidence interval 80.0, 114.3) and from nonmalignant respiratory diseases was also reduced. There were no significant trends for either cause of death according to duration of employment or time since first employment. Uterine cancer among women was the only cause of death with a significantly increased standardized mortality ratio. Five of the seven women worked in office jobs. This study confirmed the lack of an increase in mortality from lung cancer and nonmalignant respiratory diseases related to insoluble beryllium compounds.
本研究调查了肺癌及其他与难溶性铍化合物相关的疾病。对来自美国四家难溶性铍制造工厂的4950名工人组成的队列进行了随访，直至2009年。使用当地和全国死亡率计算预期死亡人数。基于当地死亡率，全因死亡率显著降低。肺癌死亡率（标准化死亡比96.0；95%置信区间80.0, 114.3）和非恶性呼吸道疾病死亡率也有所降低。根据就业时长或首次就业后的时间，两种死因均无显著趋势。女性子宫癌是唯一标准化死亡比显著升高的死因。七名女性中有五名从事办公室工作。本研究证实，与难溶性铍化合物相关的肺癌和非恶性呼吸道疾病死亡率并未增加。
