Department of Radiation Oncology, Maria Sklodowska-Curie Memorial Cancer Center and the Institute of Oncology, 44-101, ul. Wybrzeże Armii Krajowej 15, Gliwice, Poland,
Strahlenther Onkol. 2014 May;190(5):480-4. doi: 10.1007/s00066-014-0603-7. Epub 2014 Mar 4.
The aim of this study was to quantify the impact of initial tumor volume (TV) on radiotherapy (RT) outcome in patients with T2 glottic cancer.
Initial TV was calculated for 115 consecutive patients with T2 glottic cancer who had been treated with definitive RT alone at a single institution.
The results showed strong correlations of TV with 3-year local tumor control (LTC) and disease-free survival (DFS). For TV ≤ 0.7 cm(3), 3-year LTC was 83%; for TV 0.7-3.6 cm(3) this was 70% and for TV 3.6-17 cm(3) 44%. Analysis of total dose vs. initial TV showed that larger T2 glottic tumors with a TV of around 5 cm(3) (2-2.5 cm in diameter with 10(10) cancer cells) need an extra 6.5 Gy to achieve similar 3-year LTC rates as for small tumors with a TV of 0.5 cm(3) (~1 cm in diameter with 10(9) cancer cells).
Although classification of tumors according to TV cannot replace TNM staging in daily practice, it could represent a valuable numerical supplement for planning the optimal dose fractionation scheme for individual patients.
本研究旨在量化初始肿瘤体积（TV）对 T2 声门型喉癌患者放射治疗（RT）结局的影响。
在一家机构中，对 115 例连续的 T2 声门型喉癌患者进行了单纯根治性 RT 治疗，对每位患者的初始 TV 进行了计算。
结果显示 TV 与 3 年局部肿瘤控制率（LTC）和无病生存率（DFS）密切相关。对于 TV≤0.7cm³，3 年 LTC 为 83%；TV 为 0.7-3.6cm³时，3 年 LTC 为 70%；而当 TV 为 3.6-17cm³时，3 年 LTC 为 44%。总剂量与初始 TV 的分析表明，对于 TV 约为 5cm³（直径 2-2.5cm，有 10¹⁰ 个癌细胞）的较大 T2 声门型肿瘤，需要额外增加 6.5Gy，才能达到与 TV 为 0.5cm³（直径 1cm，有 10⁹ 个癌细胞）的小肿瘤相似的 3 年 LTC 率。
尽管根据 TV 对肿瘤进行分类不能替代 TNM 分期在日常实践中的作用，但它可以为规划个体化患者最佳剂量分割方案提供有价值的数值补充。
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